UM-UC-14 (Human transitional cell carcinoma of the renal pelvis) cell line

A human upper tract urothelial carcinoma model derived from the renal pelvis, used to study FGFR signaling and therapeutic response mechanisms. Save 30% on this cell line this summer. Use code SUM26CELL at checkout.

Contributors

Inventor Institute
H. Grossman ; Anita Sabichi University of Michigan
SKU: 160443
Product description: UM-UC-14 are a human transitional cell carcinoma of the renal pelvis. These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumour growth in nude mice and differences in genetic alterations. Tumorigenicity studies in nude mice revealed the UM-UC-14 produced tumours, 1-1.5 cm in diameter in < 3 weeks. This cell line demonstrated efficient gene transduction via an adenoviral vector when compared to several of the other cells evaluated. UM-UC-14 also demonstrated one of the highest levels of Coxsackie adenovirus receptor expression of the cells tested. These assays allowed for characterization of some of the most important features in each of the respective lines in an effort to more accurately establish commonly observed phenomena across cells of the same type of neoplasm.
Alternate name: UM-UC-14; UMUC-14; UM-UC14; UMUC14; University of Michigan-Urothelial Carcinoma-14
Cellosaurus ID: CVCL_2747
Disease: Cancer
Cat. #: 160443
Unit size: 1×10^6 cells / vial
Cancer types: Bladder cancer
Research Fields: Cancer
Organism: Human
Tissue: Bladder
Model: Tumourigenic cell line
Growth properties: Adherent
Cancer Types In Detail: Human bladder transitional cell carcinoma
Initial handling information: UM-UC-14 cells are highly sensitive to centrifugation; centrifugation is not recommended.
Format: Frozen
Shipping conditions: Dry ice
Growth medium: Culture medium: EMEM (EBSS) + 2mM Glutamine + 1% Non Essential Amino Acids (NEAA) + 10% Foetal Bovine Serum (FBS).
Subculture routine: Culture conditions: 37°C with 5% CO₂ Sub-culture routine: Split sub-confluent cultures (70-80%) 1:4 to 1:10 i.e. seeding at 2-4×10,000 cells/cm² using 0.05% trypsin/EDTA; 5% CO₂ 37°C. Please see data sheet for detailed growth instructions
References:

Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.

Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.

Images

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UM-UC-14 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

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