#151674

PEO6 Cell Line

Cat. #151674

PEO6 Cell Line

Cat. #: 151674

Unit size: 1x10^6 cells / vial

Organism: Human

Tissue: Ovary

Disease: Cancer

Model: Tumour line

£575.00

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Contributor

Inventor: Simon Langdon

Institute: Cancer Research UK Edinburgh Centre

Tool Details
Handling
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: PEO6 Cell Line
  • Cancer: Adenocarcinoma
  • Cancers detailed: Adenocarcinoma
  • Research fields: Cancer;Drug development
  • Organism: Human
  • Tissue: Ovary
  • Disease: Cancer
  • Growth properties: Adherent
  • Model: Tumour line
  • Conditional: Yes
  • Description: The PEO6 cell line is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated serous adenocarcinoma. The patient previously received cisplatin, 5-fluorouracil and chlorambucil treatment. PEO6 was collected at advanced, terminal stage disease. PEO6 is tumourigenic in immunologically-deprived CBA mice. PEO6 exhibits good growth in semi-solid medium (agar). PEO6 is from the same patient as the PEO1 and PEO4 cell lines This cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists.
  • Cellosaurus id: CVCL_2691

Handling

  • Format: Frozen
  • Growth medium: Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 104 cells/cm2 using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37?‚°C. Doubling time approximately 77 hours. RPMI-1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum.
  • Unit size: 1x10^6 cells / vial
  • Shipping conditions: Dry ice

Related Tools

  • Related tools: PEO1 Cell Line ; PEO4 Cell Line ; PEO14 Cell Line ; PEO16 Cell Line ; PEO23 Cell Line ; PEO1-CDDP Cell Line ; TO14 Cell Line ; PEA1 Cell Line ; PEA2 Cell Line

References

  • Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.
  • Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.
  • Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.
  • Oestrogen receptor expression and the effects of oestrogen and tamoxifen on the growth of human ovarian carcinoma cell lines.
  • Degos et al. 1979. Gastroenterol Clin Biol. 3(10):735-9. PMID: 316786.
  • [The natural history of gastrointestinal bleeding in patients with alcoholi...