PEO6 Cell Line

PEO6 is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated serous adenocarcinoma.

Contributors

Inventor Institute
Simon Langdon Cancer Research UK Edinburgh Centre
Cat. #: 151674
Tool sub type: 10XUAS IVS p10
Unit size: 1×10^6 cells / vial
Organism: Human
Tissue: Ovary
Gender: Male
Model: Tumour line
Growth properties: Adherent
Alternate name: peo6; PE06; PEO-6
Product description: The PEO6 cell line is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated serous adenocarcinoma. The patient previously received cisplatin, 5-fluorouracil and chlorambucil treatment. PEO6 was collected at advanced, terminal stage disease. PEO6 is tumourigenic in immunologically-deprived CBA mice. PEO6 exhibits good growth in semi-solid medium (agar). PEO6 is from the same patient as the PEO1 and PEO4 cell lines This cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists.
Gender: Male
CRISPR: Yes
Conditional: Yes
Cellosaurus ID: CVCL_2691
Format: Frozen
Shipping conditions: Dry ice
Growth medium: Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 104 cells/cm2 using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37?‚°C. Doubling time approximately 77 hours. RPMI-1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum.
Mycoplasma free: Yes
References:

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Degos et al. 1979. Gastroenterol Clin Biol. 3(10):735-9. PMID: 316786.

Images

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PEO6 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

Citations And Reviews

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