UM-UC-5 (Human squamous cell carcinoma of the bladder) cell line

UM-UC-5 is a human urothelial carcinoma cell line established from a primary bladder tumour of a female patient, developed at the University of Michigan

Contributors

Inventor Institute
H. Grossman ; Anita Sabichi University of Michigan
Cat. #: 160437
Unit size: 1×10^6 cells / vial
Cancer types: Genitourinary cancer
Research Fields: Cancer
Organism: Human
Tissue: Bladder
Model: Cancer Model
Growth properties: Adherent
Cancer Types In Detail: Human bladder transitional cell carcinoma
Alternate name: UM-UC-5; UMUC5; University of Michigan-Urothelial Carcinoma-5
Product description: UM-UC-5 is a human urothelial cell carcinoma cell line established from a primary bladder tumour of a female patient. The UM-UC panel of urothelial carcinoma is a diverse range of 11 patient derived cell lines developed by the university of Michigan that have been well-categorised in the literature. These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumour growth in nude mice and differences in genetic alterations.
Conditional: Yes
disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
Growth medium: Cells were grown in EMEM (EBSS) + 2mM Glutamine + 1% Non Essential Amino Acids (NEAA) + 10% Foetal Bovine Serum (FBS).
Subculture routine: -confluent cultures (70-80%) 1:4 to 1:10 i.e. seeding at 2-4×10,000 cells/cm2; using 0.05% trypsin/EDTA; 5% CO2, 37°C. Doubling time approximately 19 hours.
References:

Grossman et al. 1986. J Urol. 136(5):953-9. PMID: 3761468

Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639

Allory et al. 2014. Eur Urol. 65(2):360-6. PMID: 24018021

Earl et al. 2015. BMC Genomics. 16:403. PMID: 25997541

Zuiverloon et al. 2018. Bladder Cancer. 4(2):169-83. PMID: 2973238

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