UM-UC-11 (Human transitional cell carcinoma of the bladder) cell line

A patient-derived bladder cancer model used to study immune signalling mechanisms, biomarker discovery, and therapeutic response.

Contributors

Inventor Institute
H. Grossman ; Anita Sabichi University of Michigan
SKU: 160441
Product description: UM-UC-11 is a human transitional cell carcinoma cell line that is non-tumorigenic in nude mice. This cell line demonstrates efficient gene transduction capabilities. The UM-UC panel of urothelial carcinoma is a diverse range of 11 patient derived cell lines developed by the university of Michigan that have been well-categorised in the literature. These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumour growth in nude mice and differences in genetic alterations.
Alternate name: UM-UC-11; UM-UC11; UMUC11; UC-11; University of Michigan-Urothelial Carcinoma-11
Conditional: Yes
Cellosaurus ID: CVCL_2745
Disease: Cancer
Cat. #: 160441
Unit size: 1×10^6 cells / vial
Cancer types: Bladder cancer
Research Fields: Cancer
Organism: Human
Tissue: Bladder
Model: Tumour cell line
Growth properties: Adherent
Cancer Types In Detail: Human bladder transitional cell carcinoma
Format: Frozen
Shipping conditions: Dry ice
Growth medium: EMEM (EBSS) + 2mM Glutamine + 1% Non Essential Amino Acids (NEAA) + 10% Foetal Bovine Serum (FBS).
Subculture routine: Split sub-confluent cultures (70-80%) 1:3 to 1:6 i.e. seeding at 2-4×10,000 cells/cm2; using 0.05% trypsin/EDTA; 5% CO2; 37°C
References:

Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.

Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.

Images

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UM-UC-11 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

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