UM-UC-3 (Human bladder transitional cell carcinoma) cell line

UM-UC-3 are a human transitional cell carcinoma of the bladder.

Contributors

Inventor Institute
H. Grossman ; Anita Sabichi University of Michigan
Cat. #: 160434
Unit size: 1×10^6 cells / vial
Cancer types: Bladder cancer
Research Fields: Cancer
Organism: Human
Tissue: Bladder
Model: Tumourigenic cell line
Growth properties: Adherent
Cancer Types In Detail: Human bladder translational cell carcinoma
Alternate name: UM-UC-3; UM-UC3; UMUC3; University of Michigan-Urothelial Carcinoma-3
Product description: UM-UC-3 is a hypotriploid human urothelial carcinoma cell line established from urinary bladder transitional cell carcinoma. This cell line features a modal chromosome number of 80 (~42% of cells) and demonstrates rapid tumorigenicity in vivo. UM-UC-3 was more resistant to adenoviral gene transduction than several of the other cells evaluated. This cell line had intermediate levels of Coxsackie adenovirus receptor (CAR) expression of the cells tested. UM-UC-3 is among a panel of 11 human urothelial cancer cell lines deposited by the University of Michigan.
Disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
Growth medium: EMEM EBSS + 2mM Glutamine + 0.1mM Non Essential Amino Acids (NEAA) + 10% Foetal Bovine Serum (FBS) + 1.5g/L sodium bicarbonate + 1.0mM sodium pyruvate.
Subculture routine: Split sub-confluent cultures (70-80 %) 1:4 to 1:10 i.e. seeding at 3-5×10,000 cells/cm² using 0.05% trypsin/EDTA; 37°C; 5% CO2
References:

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UM-UC-3 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC).

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