Cat. #160436
UM-UC-1 (Human bladder transitional cell carcinoma) cell line
Cat. #: 160436
Unit size: 1x10^6 cells / vial
Organism: Human
Tissue: Lymphatic Tissue
Disease: Cancer
Model: Tumourigenic cell line
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: H. Grossman ; Anita Sabichi
Institute: University of Michigan
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: UM-UC-1 (Human bladder transitional cell carcinoma) cell line
- Alternate name: UM-UC-1; UMUC1; University of Michigan-Urothelial Carcinoma-1
- Cancer type filter: Bladder cancer
- Cancers detailed: Human bladder translational cell carcinoma
- Research fields: Cancer
- Organism: Human
- Tissue: Lymphatic Tissue
- Disease: Cancer
- Growth properties: Adherent
- Model: Tumourigenic cell line
- Description: UM-UC-1 is a well-characterised human urothelial carcinoma cell line derived from lymphatic metastases of grade II transitional cell carcinoma from a 26-year old male patient. This tumorigenic cell line demonstrates rapid tumour formation in nude mice (1-1.5cm diameter in <3 weeks) and exhibits strong p53 nuclear overexpression by IHC analysis. This cell line has a high level of coxsackie adenovirus receptor. UM-UC-1 was more resistant to adenoviral gene transduction than several of the other cells evaluated. UM-UC-1 is part of the comprehensive 11 cell UM-UC panel deposited by the university of Michigan
Handling
- Format: Frozen
- Growth medium: Cells were grown in MEM + 1% NEAA + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
- Subculture routine: Split sub confluent cultures (70-80%) 1:4 to 1:10 i.e. seeding at 2-4x10,000 cells/cm2; using 0.05% trypsin or trypsin/EDTA; 5% CO2, 37°C. Doubling time approximately 26 hours.
Related Tools
- Related tools: UM-UC-4 (Human adenocarcinoma lymph node metastasis) cell line ; UM-UC-3 (Human bladder transitional cell carcinoma) cell line ; UM-UC-5 (Human squamous cell carcinoma of the bladder) cell line ; UM-UC-7 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-9 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-10 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-11 (Human transitional cell carcinoma of the bladder) cell line ; UM-UC-13 (Human...
References
- Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.
- Grossman et al. 1986. J Urol. 136(5):953-9. PMID: 3761468.
- Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.
- Park et al. 2008. J Natl Cancer Inst. 100(19):1401-11. PMID: 18812553.
- Chiong et al. 2009. J Urol. 181(6):2737-45. PMID: 19375735.
- Barretina et al. 2012. Nature. 483(7391):603-7. PMID: 22460905. Guo et al. 2013. J Pathol. 230(1):17-27. PMID: 23401075.
- Klijn et al. 2015. Nat Biotechnol. 33(3):306-12. PMID: 25485619.
- Yu et al. 2015. Nature. 520(7547):307-11. PMID: 25877200.
- Earl et al. 2015. BMC Genomics. 16:403. PMID: 25997541.
- Scholtalbers et al. 2015. Genome Med. 7:118. PMID: 26589293.
- Nickerson et al. 2017. Oncogene. 36(1):35-46. PMID: 27270441.
- Zuiverloon et al. 2018. Bladder Cancer. 4(2):169-83. PMID: 29732388.
- Dutil et al. 2019. Cancer Res. 79(6):1263-73. PMID: 30894373.
- Ghandi et al. 2019. Nature. 569(7757):503-8. PMID: 31068700.
