JIM3 Cell Line

JIM3 was established from plasma myeloma cells derived from pleural fluid of an advanced multiple myeloma patient, and is homoplastic with the cell line JIM1. It allows in vitro study and comparison of genetic instability in myeloma tumour lines and in vitro study of the effects of DNA repair deficiency in myeloma tumour lines.

Contributors

Inventor Institute
M.S. Hamilton University of Birmingham
Cat. #: 151450
Tool sub type: Primary
Unit size: 1×10^6 cells / vial
Cancer types: Blood cancer
Research Fields: Cancer;Drug development;Genetics
Organism: Human
Tissue: Blood
Gender: Female
Model: Tumour line
Cancer Types In Detail: Human multiple myeloma
Product description: JIM3 was established from plasma myeloma cells derived from pleural fluid of an advanced multiple myeloma patient, and is homoplastic with the cell line JIM1. It allows in vitro study and comparison of genetic instability in myeloma tumour lines and in vitro study of the effects of DNA repair deficiency in myeloma tumour lines.
Gender: Female
Conditional: Yes
Production details: Derived from plasma myeloma cells from pleural fluid of advanced multiple myeloma female patient.
Cellosaurus ID: CVCL_2533
Disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
Growth medium: Dexter culture medium, consisting of Fischer's medium + 20% FCS +10-7 M hydrocortisone sodium succinate. Seed at 2-9 x 10 5 cells/cm3 5% CO2; 37 °C
References:

Leone et al. 2008. Clin Cancer Res. 14(19):6033-41. PMID: 18829482.

Deletions of CDKN2C in multiple myeloma: biological and clinical implications.

Velangi et al. 2004. Carcinogenesis. 25(10):1795-803. PMID: 15142887.

DNA mismatch repair pathway defects in the pathogenesis and evolution of myeloma.

Hamilton et al. 1991. Leukemia. 5(9):768-71. PMID: 1943229.

Normal and neoplastic human plasma cells express bcl-2 antigen.

Images

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JIM3 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

Citations And Reviews

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