UM-UC-13 (Human transitional cell carcinoma lymphatic metastasis) cell line

UM-UC-13 are a human transitional cell carcinoma originating from lymphatic metastases of transitional cell carcinomas of the bladder of a 26-year old black male.

Contributors

Inventor Institute
H. Grossman ; Anita Sabichi University of Michigan
Cat. #: 160442
Tool sub type: 10XUAS IVS p10
Unit size: 1×10^6 cells / vial
Cancer types: Bladder cancer
Research Fields: Cancer;Cancer
Organism: Human
Tissue: Lymphatic Tissue
Gender: Male
Model: Tumourigenic cell line
Growth properties: Adherent
Cancer Types In Detail: Human bladder transitional cell carcinoma;Human bladder transitional cell carcinoma
Alternate name: UM-UC-13; UMUC13; UC-13; University of Michigan-Urothelial Carcinoma-13
Product description: UM-UC-13 are a human transitional cell carcinoma originating from lymphatic metastases of transitional cell carcinomas of the bladder of a 26-year old black male. These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumor growth in nude mice and differences in genetic alterations. Tumorigenicity studies in nude mice revealed the UM-UC-13 produced tumors, 1-1.5 cm in diameter in 1 month. UM-UC-13 demonstrated efficient gene transduction via an adenoviral vector when compared to several of the other cells evaluated. UM-UC-13 also demonstrated no sign of Coxsackie adenovirus receptor (CAR) expression. These assays allowed for characterization of some of the most important features in each of the respective lines in an effort to more accurately establish commonly observed phenomena across cells of the same type of neoplasm.
Gender: Male
CRISPR: Yes
Conditional: Yes
Disease: Cancer;Cancer
Format: Frozen
Shipping conditions: Dry ice
Growth medium: Cells were grown in EMEM (EBSS) + 2mM Glutamine + 1% Non Essential Amino Acids (NEAA) + 10% Foetal Bovine Serum (FBS).
Subculture routine: Split sub-confluent cultures (70-80%) 1:3 to 1:6 i.e. seeding at 1-2×10,000 cells/cm2 using 0.05% trypsin/EDTA; 5% CO2 37°C
Mycoplasma free: Yes
References:

Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.

Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.

Images

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UM-UC-13 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

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