#153817

CMV4pFlagSiR TDP43 F4L Vector

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Cat. #153817

CMV4pFlagSiR TDP43 F4L Vector

Cat. #: 153817

Sub-type: pFLAG-CMV4

Availability: Please enquire for quantities and pricing

Target: Mutant TDP43 not able to bind RNA

Bacterial Resistance: Ampicillin

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Prof Emanuele Buratti

Institute: International Centre For Genetic Engineering And Biotechnology (ICGEB)

Tool Details
Target Details
Application Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: CMV4pFlagSiR TDP43 F4L Vector
  • Alternate name: TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10
  • Research fields: Genetics;Neurobiology;Microbiology
  • Tool sub type: pFLAG-CMV4
  • Backbone size without insert: 6271
  • Bacterial resistance: Ampicillin
  • Description: Concentration 1.2mg/ml
  • Additional notes: The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS).

Target Details

  • Target: Mutant TDP43 not able to bind RNA

Application Details

  • Application notes: Concentration 1.2mg/ml

References

  • Ayala et al. 2008. J Cell Sci. 121(Pt 22):3778-85. PMID: 18957508.
  • Structural determinants of the cellular localization and shuttling of TDP-43.