1-7HB2 Cell Line

1-7HB2 cell line is a clonal derivative of the human mammary luminal epithelial cell line MTSV1-7 identified by screening for branching morphology

Contributors

Inventor Institute
Joyce Taylor-Papadimitriou Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151445
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Research Fields: Cell biology
Organism: Human
Tissue: Breast
Model: Immortalised Line
Growth properties: Morphology, adhesion properties
Product description: The 1-7HB2 cell line is a clonal derivative of the human mammary luminal epithelial cell line MTSV1-7 identified by screening for branching morphology. It is a potent tool for in vitro study of branching morphogenesis of human mammary epithelial cells and the role of integrins in mammary morphogenesis. MTSV1-7 is a clonal non-tumourigenic cell line developed by immortalizing luminal epithelial cells cultured from milk using the SV40 T antigen. The cell line forms branching structures in the presence of fibroblast cultures or fibroblast-conditioned medium and forms spheroids in collagen type I gels.
Cellosaurus ID: CVCL_2261
Parental cell line: MTSV1-7
disease: Normal
Format: Frozen
Shipping conditions: Dry ice
Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + Hydrocortisone (5 ?„?žg/ml) + Bovine Insulin (10 ?„?žg/ml).
References:

Bartek et al. 1991. Proc Natl Acad Sci U S A. 88(9):3520-4. PMID: 1708884.

Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus.

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