Model glioma heterogeneity, progression and treatment response with confidence

Introduction

Well‑characterised, patient‑derived glioma models capturing tumour cell states, disease progression and clinically relevant diversity

Glioma research demands models that reflect tumour heterogeneity, cellular state and disease progression. Our brain cancer portfolio enables researchers to:

• Interrogate glioblastoma heterogeneity and cell states using glioma stem cell models with deep molecular characterisation 

• Compare clinically relevant disease contexts with patient‑derived models spanning primary and relapse glioblastoma 

• Model tumour evolution and progression using IDHmutant glioma models representing low-grade disease state 

All models are built by leading cancer experts and global institutes, with traceable origins – giving you confidence in research integrity and reproducibility.

Feature brain cancer models

Human | Glioblastoma stem-like models (IDH-wildtype)

Developed by Steven Pollard, Gillian Morrison (University of Edinburgh)

Interrogate glioblastoma heterogeneity and transcriptional cell states using deeply characterised, patient‑derived glioma stem cell models.

Key features

• Deep molecular characterisation including transcriptomic, genomic and DNA methylation profiling, capturing glioblastoma transcriptional states across established frameworks 

• Patient‑derived glioma stem cell models that retain tumour heterogeneity and stem‑like characteristics 

• Grown as adherent, laminin‑dependent monolayers, enabling consistent and scalable experimental workflows 

Applications

• Compare treatment response across molecular subtypes 

• Screen compounds and identify candidate hits in vitro and in vivo  

• Investigate how stem‑like cell states influence tumour progression 

Discover the GCGR cell lines

Tool name	Cat. #	Inventor/ Institute	Organism	Key attributes
GCGR-E43	140075	Steven Pollard, Gillian Morrison University of Edinburgh	Human	– Classical GBM line, – Part of a panel of patient-derived glioma stem cell lines
GCGR-E63	140084	Steven Pollard, Gillian Morrison University of Edinburgh	Human	– Classical GBM line, – Part of a panel of patient-derived glioma stem cell lines
GCGR-E20	140061	Steven Pollard, Gillian Morrison University of Edinburgh	Human	– Proneural GBM line, – Part of a panel of patient-derived glioma stem cell lines
GCGR-E53	140077	Steven Pollard, Gillian Morrison University of Edinburgh	Human	– Proneural GBM line, – Part of a panel of patient-derived glioma stem cell lines
GCGR-E55	140079	Steven Pollard, Gillian Morrison University of Edinburgh	Human	– Mesenchymal GBM line, – Part of a panel of patient-derived glioma stem cell lines
GCGR-E57	140081	Steven Pollard, Gillian Morrison University of Edinburgh	Human	– Mesenchymal GBM line, – Part of a panel of patient-derived glioma stem cell lines

Human | Glioma models (Heidelberg collection)

Developed by Christel Herold-Mende (University of Heidelberg)

Model glioma initiation, progression, and transition to high‑grade disease using patient‑derived IDH‑mutant glioma stem‑like cell lines.

High-Grade Glioblastoma models (IDH-Wildtype)

Key features

• Derived from primary and relapsed WHO grade IV glioblastoma tumours 

• Represents the major molecular subtypes and MGMT promoter states 

• Models from both primary tumours and relapse models

Applications

• Model relapse and therapy resistance 

• Compare treatment response across glioblastoma models and molecular subtypes 

Discover the high grade glioblastoma models

Tool name	Cat. #	Inventor/ Institute	Organism	Key attributes
NCH57	162334	Christel Herold-Mende University of Heidelberg	Human	Rare Gliosarcoma model
NCH1425	162333	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH741f	162332	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH711d	162331	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH705	162330	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH669	162329	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH663	162328	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH660h	162327	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH627	162326	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH601	162325	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH592b	162324	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH588j	162323	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH481	162322	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH465	162321	Christel Herold-Mende University of Heidelberg	Human	Neurosphere models of Glioblastoma
NCH676	162320	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH474	162319	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH453	162318	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH417	162317	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH354	162316	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH343	162315	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH342	162314	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH270	162313	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH210	162312	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH156	162311	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH149	162310	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH125	162309	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH89	162308	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH82	162306	Christel Herold-Mende University of Heidelberg	Human	Adherent Glioblastoma models
NCH93	162305	Christel Herold-Mende University of Heidelberg	Human	Rare Meningioma model with deleterious NF2 frameshift deletion, missense ALK and PTCH1 mutation

Low grade glioma models (IDHmutant astrocytoma)

Key features

• Derived from astrocytoma relapse samples, reflecting tumour evolution from lower‑grade disease 

• IDH‑mutant background with defined MGMT and BRAF status reported in primary tumours 

• Maintained as neurosphere cultures under serum‑free conditions 

Applications

• Model progression from low‑grade glioma 

• Investigate how IDH mutation status shapes tumour biology 

Discover the IDH mutant low grade cell lines

Tool name	Cat. #	Inventor/ Institute	Organism	Key attributes
NCH3763	162307	Christel Herold-Mende University of Heidelberg	Human	Low-grade Glioma models, IDHmutant Astrocytoma relapse models
NCH1681	162304	Christel Herold-Mende University of Heidelberg	Human	Low-grade Glioma models, IDHmutant Astrocytoma relapse models
NCH645	162303	Christel Herold-Mende University of Heidelberg	Human	Low-grade Glioma models, IDHmutant Astrocytoma relapse models
NCH620	162302	Christel Herold-Mende University of Heidelberg	Human	Low-grade Glioma models, IDHmutant Astrocytoma relapse models
NCH551b	162301	Christel Herold-Mende University of Heidelberg	Human	Low-grade Glioma models, IDHmutant Astrocytoma relapse models

Discover more brain cancer tools

Tool name	Cat. #	Inventor/ Institute	Organism	Key attributes
NCH57	162334	Christel Herold-Mende University of Heidelberg	Human	Rare Gliosarcoma model
NCH93	162305	Christel Herold-Mende University of Heidelberg	Human	Rare Meningioma model with deleterious NF2 frameshift deletion, missense ALK and PTCH1 mutation