Melan-coa cell line

immortal melanocyte cell line derived from the skin of neonatal coa/coa Ink4aArf -/- C57BL/10J mice

Contributors

Inventor Institute
Elena Sviderskaya St. George's University London
Cat. #: 162008
Organism: Mouse
Tissue: Skin
Model: Immortalised non-cancerous cell lines
Morphology: Small, oval-fusiform
Primary citation: Suzuki T, et al. Genomics. 2001 Nov;78(1-2):30-7. PMID: 11707070
Product description: The melan-coa cell line is an immortal melanocyte cell line derived from the skin of neonatal coa/coa Ink4aArf -/- C57BL/10J mice. These cell lines lack HPS-3, a subunit of the biogenesis of lysosome-related organelles complex 2 (BLOC-2). The role of BLOC-2 is incompletely understood; however, it is involved in melanogenic cargo delivery to melanosomes. Pathogenic variants in the human ortholog of HPS3 cause a form of Hermansky-Pudlak syndrome (HPS), HPS type 3. HPS is a group of disorders characterised by hypopigmentation, bleeding tendency and other variable symptoms. These cells are mildly hypopigmented. These cells are a useful model for HPS and for the study of trafficking of cargoes towards lysosome-related organelles.
disease: Hermansky-Pudlak syndrome
Storage conditions: liquid N2
Growth medium: RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM)
References:

Suzuki T, et al. Genomics. 2001 Nov

78(1-2):30-7. PMID: 11707071

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