Cat. #162008
Melan-coa cell line
Cat. #: 162008
Availability: 8-10 weeks
Organism: Mouse
Tissue: Skin
Disease: Hermansky-Pudlak syndrome
Model: Immortalised non-cancerous cell lines
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Elena Sviderskaya
Institute: St. George's University London
Primary Citation: Suzuki T, et al. Genomics. 2001 Nov;78(1-2):30-7. PMID: 11707070
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Melan-coa cell line
- Organism: Mouse
- Tissue: Skin
- Disease: Hermansky-Pudlak syndrome
- Morphology: Small, oval-fusiform
- Model: Immortalised non-cancerous cell lines
- Description: The melan-coa cell line is an immortal melanocyte cell line derived from the skin of neonatal coa/coa Ink4aArf -/- C57BL/10J mice. These cell lines lack HPS-3, a subunit of the biogenesis of lysosome-related organelles complex 2 (BLOC-2). The role of BLOC-2 is incompletely understood; however, it is involved in melanogenic cargo delivery to melanosomes. Pathogenic variants in the human ortholog of HPS3 cause a form of Hermansky-Pudlak syndrome (HPS), HPS type 3. HPS is a group of disorders characterised by hypopigmentation, bleeding tendency and other variable symptoms. These cells are mildly hypopigmented. These cells are a useful model for HPS and for the study of trafficking of cargoes towards lysosome-related organelles.
- Application: Melanocyte cell biology
Applications
- Application: Melanocyte cell biology
Handling
- Growth medium: RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM)
- Storage conditions: liquid N2
References
- Suzuki T, et al. Genomics. 2001 Nov
- 78(1-2):30-7. PMID: 11707071
