#151630

PDVC57B Cell Line

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Cat. #151630

PDVC57B Cell Line

Cat. #: 151630

Sub-type: Continuous

Unit size: 1x10^6 cells / vial

Organism: Mouse

Disease: Cancer

Model: Tumour line

£575.00

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Contributor

Inventor: Allan Balmain

Institute: Cancer Research UK, Glasgow: The Beatson Institute

Tool Details
Target Details
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: PDVC57B Cell Line
  • Cancer: Carcinoma
  • Cancers detailed: Carcinoma Squamous Cell
  • Research fields: Apoptosis and autophagy;Cancer;Cell biology;Drug development;Genetics
  • Tool sub type: Continuous
  • Parental cell: PDV
  • Organism: Mouse
  • Disease: Cancer
  • Growth properties: Mouse spindle cell carcinoma, Adherent
  • Model: Tumour line
  • Description: The PDVC57B Cell Line is useful for the study of the progression of carcinogenesis and as a model of relapse after surgery. PDVC57B is syngeneic for C57B1/6 mice and carries a p53 mutation in codon 231, (ATG-GTC) and an A-T tranversion at cod 61 of the H-ras gene. These events appear to be remarkably similar to the sequence of changes seen during tumour development in vivo.
  • Production details: The transformed PDVB57B was created by treating the PDV cell line with the carcinogen DMBA.
  • Cellosaurus id: CVCL_4271

Target Details

  • Target: PDVC57b

Handling

  • Format: Frozen
  • Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
  • Unit size: 1x10^6 cells / vial
  • Shipping conditions: Dry ice
  • Storage conditions: Vapor phase of liquid nitrogen. Storage at -70° C will result in loss of viability.

References

  • Oakley et al. 2002. Clin Cancer Res. 8(6):1984-1994. PMID: 12060644.
  • Quintanilla et al. 1991. Carcinogenesis. 12(10):1875-1881. PMID: 1934268.