PDVC57B Cell Line

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A syngeneic murine cutaneous squamous cell carcinoma model used to study skin carcinogenesis, tumour progression, and immunotherapy response. Exclusive to CancerTools. Save 30% on this cell line this summer. Use code SUM26CELL at checkout.

Contributors

Inventor Institute
Allan Balmain Cancer Research UK, Glasgow: The Beatson Institute
SKU: 151630
Product description: The PDVC57B Cell Line is useful for the study of the progression of carcinogenesis and as a model of relapse after surgery. PDVC57B is syngeneic for C57B1/6 mice and carries a p53 mutation in codon 231, (ATG-GTC) and an A-T transversion at cod 61 of the H-ras gene. These events appear to be remarkably similar to the sequence of changes seen during tumour development in vivo.
Production details: The transformed PDVB57B was created by treating the PDV cell line with the carcinogen DMBA.
Cellosaurus ID: CVCL_4271
Parental cell line: PDV
Disease: Cancer
Cat. #: 151630
Provenance and Ownership: The PDVC57B Cell Line is owned by Cancer Research UK. CancerTools supplies the PDVC57B Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing PDVC57B Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Skin cancer
Research Fields: Apoptosis and autophagy; Cancer; Cell biology; Drug development; Genetics
Organism: Mouse
Model: Tumour line
Growth properties: Mouse spindle cell carcinoma, Adherent
Cancer Types In Detail: Carcinoma Squamous Cell
Format: Frozen
Storage conditions: Vapor phase of liquid nitrogen. Storage at -70° C will result in loss of viability.
Shipping conditions: Dry ice
Growth medium: DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
Subculture routine: Split sub-confluent cultures (70-80%) 1:5 to 1:10 i.e. seeding at 1-5×10,000 cells/cm² using 0.05% trypsin or trypsin/EDTA; 5% CO₂; 37°C
References:

Oakley et al. 2002. Clin Cancer Res. 8(6):1984-1994. PMID: 12060644.

Quintanilla et al. 1991. Carcinogenesis. 12(10):1875-1881. PMID: 1934268.

Citations And Reviews

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