MEF Trex1 KO Cell Line

A mouse embryonic fibroblast model with TREX1 deficiency used to study Trex1-deficient Aicardi-Goutieres syndrome, DNA repair pathways, and inflammatory signalling. Save 30% on this cell line this summer. Use code SUM26CELL at checkout.

Contributors

Inventor Institute
Deborah Barnes Cancer Research UK, London Research Insitute: Clare Hall Laboratories
SKU: 151558
Product description: The Trex1 KO MEF cell line is a spontaneously transformed mouse embryonic fibroblast (MEF) cell line. It allows the study of novel interconnections between DNA replication, DNA damage checkpoint signalling and antiviral-like autoimmune responses. Recapitulates cellular phenotype of Trex1-deficient Aicardi-Goutieres syndrome. Spontaneously transformed clone derived following repeated passaging in culture by standard techniques of primary MEFs from Trex1-/- knockout mouse.
Conditional: Yes
Production details: MEF from Trex1-/- knockout mouse
Cellosaurus ID: CVCL_5A06
Disease: Trex1-deficient Aicardi-Goutieres syndrome
Cat. #: 151558
Provenance and Ownership: The MEF Trex1 KO Cell Line is owned by Cancer Research UK. CancerTools supplies the MEF Trex1 KO Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing MEF Trex1 KO Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Unit size: 1×10^6 cells / vial
Research Fields: Genetics;Immunology
Organism: Mouse
Tissue: Embryo
Model: Knock-Out
Growth properties: Defective G1/S transition, increased cell doubling time; chronic ATM-dependent checkpoint activation even in the absence of exogenous stress; persistant ssDNA polynucleotide species generated in S phase that accumulates in the cytoplasm.
Format: Frozen
Storage conditions: Vapor phase of liquid nitrogen. Storage at -70° C will result in loss of viability.
Shipping conditions: Dry ice
References:

Yang et al. 2007. Cell. 131(5):873-86. PMID: 18045533

Morita et al. 2004. Mol Cell Biol. 24(15):6719-27. PMID: 15254239

Images

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MEF Trex1 KO Cell Line. 24 hours post plating. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC).

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