Cat. #155237
Anti-Sm [Y12]
Cat. #: 155237
Unit size: 100 ug
Availability: 3-4 weeks
Target: Sm
Class: Monoclonal
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Yale University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Sm [Y12]
- Research fields: Immunology
- Class: Monoclonal
- Conjugation: Unconjugated
- Host: Mouse
- Description: Monoclonal antibody used in quantitative radioimmuno-assays in SLE patients. Background and Research Application Sm is an autoantigen on a series of particles composed of RNA and protein. It is one of several nuclear proteins that are found commonly among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Sm is involved in the pathogenesis of Systemic lupus erythematosus (SLE), with antibodies to Sm being found in 20-30% of patients with SLE. This antibody can aid in the titration of autoantibody activity in the sera of SLE patients. Anti-Sm antibody can be used to help understand the role of snRNPs, particularly within disease.
- Immunogen: P27048
- Immunogen uniprot id: P27048
- Isotype: IgG3 kappa
Target Details
- Target: Sm
- Target background: Monoclonal antibody used in quantitative radioimmuno-assays in SLE patients Background and Research Application Sm is an autoantigen on a series of particles composed of RNA and protein. It is one of several nuclear proteins that are found commonly among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Sm is involved in the pathogenesis of Systemic lupus erythematosus (SLE), with antibodies to Sm being found in 20-30% of patients with SLE. This antibody can aid in the titration of autoantibody activity in the sera of SLE patients. Anti-Sm antibody can be used to help understand the role of snRNPs, particularly within disease.
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: 4° C
- Shipping conditions: Dry ice
References
- Lerner et al. 1981. Proc Natl Acad Sci U S A. 78(5):2737-41. PMID: 6789322.
