Anti-Rb1 [Rb1 (1F8)]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-Rb1 [Rb1 (1F8)]
• Alternate name: CD4 Molecule; T-Cell Surface Antigen T4/Leu-3; T-Cell Surface Glycoprotein CD4; CD4 Receptor; CD4 Antigen
• Cancer: Breast cancer;Eye cancer
• Cancers detailed: Breast cancer;Broadly Applicable;Retinoblastoma
• Research fields: Cancer;Cell biology
• Clone: Rb1 (1F8)
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 105 kDa
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Disease: Breast Cancer
• Application: IHC ; IF ; IP
• Description: The Retinoblastoma protein (Rb) is a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription. Mutation of the Rb gene is found frequently in human sarcomas, lung, bladder and breast carcinomas and is the molecular basis for hereditary disposition to retinoblastoma.
• Immunogen: Rb-b-galactosidase fusion protein spanning nucleotides 1126-1973 and representing 283 mino acids of Human Rb cDNA
• Isotype: IgG1
• Myeloma used: Sp2/0-Ag14

Target Details

• Target: Retinoblastoma (Rb1)
• Molecular weight: 105 kDa
• Target background: The Retinoblastoma protein (Rb) is a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription. Mutation of the Rb gene is found frequently in human sarcomas, lung, bladder and breast carcinomas and is the molecular basis for hereditary disposition to retinoblastoma.

Applications

• Application: IHC ; IF ; IP

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

References

• Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates.
• Ragazzon et al. 2014. Eur J Endocrinol. 2014 Feb 4
• 170(3):385-91. PMID: 24347427
• Bandyopadhyay et al. 2007. Aging Cell. 6(4):577-91. PMID: 17578512.
• Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.
• Lee et al. 2007. Clin Cancer Res. 13(3):832-8. PMID: 17289874.
• Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer.
• Bartkova et al. 2003. J Pathol. 200(2):149-56. PMID: 12754735.
• Deregulation of the RB pathway in human testicular germ cell tumours.
• Brtek et al. 1992. Oncogene. 7(1):101-8. PMID: 1741157.
• Cellular localization and T antigen binding of the retinoblastoma protein.
• Grand et al. 1989. Oncogene. 4(11):1291-8. PMID: 2682458.
• The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells.