The Retinoblastoma protein (Rb) is a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription.
| Inventor | Institute |
|---|---|
| David Lane | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151156 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Breast cancer;Eye cancer |
| Research Fields: | Cancer;Cell biology |
| Application: | IHC ; IF ; IP |
| Target: | Retinoblastoma (Rb1) |
| Reactivity: | Human |
| Clone: | Rb1 (1F8) |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CD4 Molecule; T-Cell Surface Antigen T4/Leu-3; T-Cell Surface Glycoprotein CD4; CD4 Receptor; CD4 Antigen |
|---|---|
| Product description: | The Retinoblastoma protein (Rb) is a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription. Mutation of the Rb gene is found frequently in human sarcomas, lung, bladder and breast carcinomas and is the molecular basis for hereditary disposition to retinoblastoma. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 105 kDa |
| Immunogen: | Rb-b-galactosidase fusion protein spanning nucleotides 1126-1973 and representing 283 mino acids of Human Rb cDNA |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | The Retinoblastoma protein (Rb) is a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription. Mutation of the Rb gene is found frequently in human sarcomas, lung, bladder and breast carcinomas and is the molecular basis for hereditary disposition to retinoblastoma. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates. Ragazzon et al. 2014. Eur J Endocrinol. 2014 Feb 4 170(3):385-91. PMID: 24347427 Bandyopadhyay et al. 2007. Aging Cell. 6(4):577-91. PMID: 17578512. Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Lee et al. 2007. Clin Cancer Res. 13(3):832-8. PMID: 17289874. Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. Bartkova et al. 2003. J Pathol. 200(2):149-56. PMID: 12754735. Deregulation of the RB pathway in human testicular germ cell tumours. Brtek et al. 1992. Oncogene. 7(1):101-8. PMID: 1741157. Cellular localization and T antigen binding of the retinoblastoma protein. Grand et al. 1989. Oncogene. 4(11):1291-8. PMID: 2682458. The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells. |
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