Phosphorylation of Rb at S608 depends on CDK4.
| Inventor | Institute |
|---|---|
| Sibylle Mittnacht | The Institute of Cancer Research |
| Cat. #: | 153190 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Breast cancer, Eye cancer |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction;Genetics;Stem cell biology |
| Application: | IHC ; WB |
| Target: | Rb (phospho Thr356) |
| Reactivity: | Human ; Mouse |
| Clone: | 7F10 |
| Host: | Rat |
| Class: | Monoclonal |
| Alternate name: | Retinoblastoma 1; RB1; p15-Rb; RB; pp11; pRb; OSRC |
|---|---|
| Product description: | Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia. Phosphorylation of Rb at S608 depends on CDK4. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 111 kDa |
| Immunogen: | Synthetic peptide COOH-C-ERERpTPRKNN-NH2 coupled to mycobacterium tuberculosis PPD |
| Target background: | Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia. Phosphorylation of Rb at S608 depends on CDK4. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Barrie et al. 2003. Anal Biochem. 320(1):66-74. PMID: 12895470. High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells. |
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