TR146 Cell Line

A human buccal squamous cell carcinoma cell line used to study oral drug delivery, mucosal barrier function, and head and neck cancer biology. Available exclusively through CancerTools. Save 30% on this cell line this summer. Use code SUM26CELL at checkout.

Contributors

Inventor Institute
Bridget Hill Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151425
Product description: Cell line to investigate buccal mucosa, and as a model for absorption and metabolism of various substances and enzymatically labile drugs.
Alternate name: Tr146; TR-146; TR 146
Gender: Female
CRISPR: No
Conditional: Yes
Production details: The TR146 cell line originates from a human neck metastasis of a buccal carcinoma, derived from neck node (primary tumour sited in buccal mucosa). Well-differentiated. Female patient, 67 years. Previous radiotherapy (6,000 rads) and neck dissection
Additional notes: Histology: well-differentiated keratinizing squamous cell carcinoma. Cell type: polygonal
Cellosaurus ID: CVCL_2736
Model description: TR146 cell ine is tumourigenic in female (nu/nu) mice resulting in the production of rapidly progressing tumours
Disease: Cancer
Cat. #: 151425
Provenance and Ownership: The TR146 Cell Line is owned by Cancer Research UK. CancerTools supplies the TR146 Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing TR146 Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Unit size: 1×10^6 cells / vial
Research Fields: Cancer; Drug development; Metabolism
Organism: Human
Tissue: Buccal mucosa that had infiltrated a lymph node
Gender: Female
Model: Tumourigenic cell line
Growth properties: Adherent
Cancer Types In Detail: Human neck metastasis
Primary citation: Rupniak et al. 1985. J Natl Cancer Inst. 75(4):621-35. PMID: 2413234
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Growth medium: HAMS F12 + 2mM Glutamine + 10% Foetal Bovine Serum (FBS)
Subculture routine: Split sub-confluent cultures (70-80%) seeding at approximately 1-2 x 10^4 cells/cm2 using 0.05% trypsin or trypsin/EDTA; 5% CO2; 37°C. Cells can reach a maximum density of 7 x 10^4 cells/cm2. Please also see detailed protocol within the Product Datasheet in the Documentation section below.
Temperature: 37°C
Atmosphere: 5% CO2
Mycoplasma free: Yes
Biosafety level: 1
References:

Lin et. al. 2021. Pharmaceutics 13(2):256. PMID: 33673378

Mogavero and Hube. 2021. Methods Mol Biol 2260:133-143. PMID: 33405035

Lin et. al. 2020. Tissue Barriers 8(2): 1784644. PMID: 32614652

Rupel et.al. 2019. NPJ Biofilms Microbiomes. 5: 29. PMID: 31602310

Laurén et.al. 2018. Pharm Res. 22,35(7):145. PMID 29790010

Kalu et al. 2017. Oncotarget. 8(49):86369-86383. PMID: 29156801

Li et al. 2017. Cancer Cell. 31(2):225-239. PMID: 28196595

Pistone et al. 2016. Eur J Pharm Sci. 96:381-389. PMID: 27721043

Nilsen et al. 2016. Eur J Oral Sci. :. PMID: 27711994

Iyire et al. 2016. Sci Rep. 6:32498. PMID: 27581177

Goyer et al. 2016. PLoS One. 11(3):e0149159. PMID: 26933885

Hyakusoku et al. 2016. J Exp Clin Cancer Res. 35:6. PMID: 26754630

Zeng et al. 2015. Int J Pharm. 495(2):1028-37. PMID: 26403384

De Ryck et al. 2015. AMB Express. 5:27. PMID: 25995981

O'Callaghan et al. 2015. Mol Med Rep. :. PMID: 26005189

Chai et al. 2012. J R Soc Interface. 9(77):3528-38. PMID: 22915635

Mrck Nielsen et al. 2000. Int J Pharm. 200(2):261-70. PMID: 10867256

Nielsen et al. 2000. Int J Pharm. 194(2):155-67. PMID: 10692640

Jacobsen et al. 1999. Eur J Pharm Biopharm. 48(3):217-24. PMID: 10612032

Nielsen et al. 1999. Int J Pharm. 185(2):215-25. PMID: 10460917

Nielsen et al. 1999. J Control Release. 60(2-3):223-33. PMID: 10425328

Pedersen et al. 1999. Drug Dev Ind Pharm. 25(4):463-70. PMID: 10194601

Jacobsen et al. 1999. Eur J Oral Sci. 107(2):138-46. PMID: 10232463

Rupniak et al. 1985. J Natl Cancer Inst. 75(4):621-35. PMID: 2413234

Images

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TR146 Cell Line. 3 days post plating. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

Citations And Reviews

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