#151131

Anti-PKCa [MC5]

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Cat. #151131

Anti-PKCa [MC5]

Cat. #: 151131

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-5 days

Target: Protein Kinase C alpha

Class: Monoclonal

Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB

Reactivity: Bovine

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Peter Parker

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-PKCa [MC5]
  • Alternate name: CD1c Molecule; CD1C Antigen; C Polypeptide; CD1c Antigen; Differentiation Antigen CD1-Alpha-3; Cortical Thymocyte Antigen; CD1C; BDCA1; CD1A; CD1; R7
  • Research fields: Cancer;Tissue-specific biology;Cell signaling and signal transduction
  • Clone: MC5
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 80 kDa
  • Strain: Balb/c
  • Reactivity: Bovine
  • Host: Mouse
  • Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB
  • Description: MC5 blocks partial proteolysis of PKC by trypsin in vitro. Fab fragment inhibits phorbol-ester-induced down-regulation of PKC in a rodent gloma cell line.
  • Immunogen: Purified bovine brain protein kinase C
  • Isotype: IgG2a
  • Myeloma used: P3X63Ag8

Target Details

  • Target: Protein Kinase C alpha
  • Molecular weight: 80 kDa
  • Target background: Protein Kinase C is a family of serine/threonine protein kinases that are activated by Ca2+, diacylglycerol and membrane phospholipids (phosphatidylserine).

Applications

  • Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Kim et al. 2008. Nature. 452(7186):478-82. PMID: 18368118.
  • Molecular identification of a retinal cell type that responds to upward motion.
  • Ng et al. 1999. EMBO J. 18(14):3909-23. PMID: 10406796.
  • PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic.
  • Young et al. 1988. Eur J Biochem. 173(1):247-52. PMID: 2451608.
  • A monoclonal antibody recognising the site of limited proteolysis of protein kinase C. Inhibition of down-regulation in vivo.