Anti-mEMILIN1 [mEMIL]

Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 interacts with the Î?4Î?1 integrin via the C-terminal gC1q domain. It binds pro-TGFB […]

Contributors

Inventor Institute
Alfonso Colombatti ; Roberto Doliana ; Paola Spessotto ; Maria Teresa Mucignat National Cancer Institute CRO – Aviano
Cat. #: 160584
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology
Application: ELISA ; IHC ; IF ; WB
Target: mEMILIN1
Reactivity: Mouse
Host: Rat
Class: Monoclonal
Product description: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 interacts with the Î?4Î?1 integrin via the C-terminal gC1q domain. It binds pro-TGFB preventing its maturation to mature TGFB in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.
Conjugation: Unconjugated
Immunogen: Recombinant murine Emilin-1 as immunizing antigen; Wistar rat as host
Target background: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 interacts with the a4?1 integrin via the C-terminal gC1q domain. It binds pro-TGFB preventing its maturation to mature TGFB in the extracellular space, therefore influencing the regulation of blood and lymph vessel…
Format: Liquid
Storage conditions: Store at 2 – 8° C or aliquots at -20° C. Avoid repeated freeze-thaw cycles
Shipping conditions: Dry ice
References:

Pivetta et al. 2016. Clin Sci (Lond). 130(14):1221-36. PMID: 26920215.

Capuano et al. 2016. Hum Mutat. 37(1):84-97. PMID: 26462740.

Danussi et al. 2013. Mol Cell Biol. 33(22):4381-94. PMID: 24019067.

Danussi et al. 2012. Cancer Prev Res (Phila). 5(9):1131-43. PMID: 22827975.

Danussi et al. 2011. J Cell Biol. 195(1):131-45. PMID: 21949412.

Danussi et al. 2008. Mol Cell Biol. 28(12):4026-39. PMID: 18411305.

Zacchigna et al. 2006. Cell. 124(5):929-42. PMID: 16530041.

Images

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Immunofluorescence on tissues. A

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