TG-1 is useful for the differentiation of human leukocytes.
| Inventor | Institute |
|---|---|
| Peter Beverley | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151165 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Immunology |
| Application: | FACS ; IHC ; IF |
| Target: | Lewis X (CD15) |
| Reactivity: | Human |
| Clone: | TG-1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Fucosyltransferase 4; Galactoside 3-L-Fucosyltransferase; ELAM-1 Ligand Fucosyltransferase; FUC-TIV; FCT3A; ELFT; Stage-Specific Embryonic Antigen; Alpha (1,3) Fucosyltransferase; EC 2.4.1.65; Lewis X; SSEA-1; FUTIV; CD15; LeX |
|---|---|
| Product description: | TG-1 is useful for the differentiation of human leukocytes. |
| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Molecular weight: | 156 kDa |
| Immunogen: | Thymocyte glycoprotein fraction adsorbed to Con A and eluted with 0.1M glucose. |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Lewis X (CD15) is a branched pentasaccharide found on neutrophils, eosinophils and monocytes. Lewis X is distributed abnormally in myeloid leukeamias and is commonly used in the diagnosis of Hodgkin's disease. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | '-15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Cho et al. 2010. J Proteome Res. 9(11):5960-8. PMID: 20858014. Sialylated Lewis x antigen bearing glycoproteins in human plasma. Hogg et al. 1984. Immunology. 53(4):753-67. PMID: 6389324. Monoclonal antibodies specific for human monocytes, granulocytes and endothelium. Linch et al. 1984. Blood. 63(3):566-73. PMID: 6365201. Monoclonal antibodies differentiating between monocytic and nonmonocytic variants of AML. Beverley et al. 1980. Nature. 287(5780):332-3. PMID: 7421991. Isolation of human haematopoietic progenitor cells using monoclonal antibodies. |
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