Cat. #162208
Anti-HSPB1p78 [2.1]
Cat. #: 162208
Sub-type: Primary antibody
Unit size: 100 ug
Target: human heat shock protein 27 phosphorylated at site 78, HSP27p78
Class: Monoclonal
Application: WB ; IP ; IHC
Reactivity: Human
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Roy Quinlan
Institute: University of Durham
Primary Citation: P A Eyers, et al. 1999. FEBS Lett. 21;451(2):191-6. PMID: 10371163
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-HSPB1p78 [2.1]
- Alternate name: HSPB1p78 ; HSP26p78
- Research fields: Cell biology
- Clone: 2.1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 27kDa, 205 residues
- Reactivity: Human
- Application: WB ; IP ; IHC
- Description: A monoclonal antibody for HSPB1p78 also known as HSP27p78. This antibody targets HSPB1 (HSP27) a small heat shock protein which is involved in TP53 turnover, steroid receptor maturation, cytoskeletal dynamics, regulation of proteostasis and apoptosis. This antibody recognises HSPB1 when phosphorylated at serine 78. Phosphorylation of HSP27 can cause conformational changes in the tertiary structure resulting in decreased oligomeric size.
- Immunogen: peptide crosslinked to KLH
- Isotype: IgG
Target Details
- Target: human heat shock protein 27 phosphorylated at site 78, HSP27p78
- Target alternate names: HSPB1p78 ; HSP26p78
- Molecular weight: 27kDa, 205 residues
- Target background: Hsp27 is an ATP-independent molecular chaperone with well-described tumorigenic and metastatic roles, characterized by its dynamic phosphorylation leading to heterogeneous oligomerization under different conditions such as stress
Applications
- Application: WB ; IP ; IHC
Handling
- Format: Liquid
- Concentration: 1mg/ml
- Unit size: 100 ug
- Storage buffer: tissue culture media with cryoprotectant
- Storage conditions: liquid nitrogen
- Shipping conditions: Dry ice
References
- Philip R Quinlan, et al. 2021. Cell Stress Chaperones. 27(2):177-188. PMID: 35235182.
- Alamgir M N Kabir, et al. 2005. J Mol Cell Cardiol. 39(4):709-17. PMID: 16140323
- P A Eyers, et al. 1999. FEBS Lett. 21
- 451(2):191-6. PMID: 10371163
