Cat. #154754
Anti-CD3 e [NKIT3a]
Cat. #: 154754
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: CD3 e
Class: Monoclonal
Application: FACS ; IP
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Netherlands Cancer Institute
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD3 e [NKIT3a]
- Alternate name: CD3E; T-Cell Surface Glycoprotein CD3 Epsilon Chain
- Research fields: Cell signaling and signal transduction;Immunology
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IP
- Description: The CD3-epsilon polypeptide together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause severe immunodeficiency.
- Immunogen: Human cytotoxic T-lymphocytes
- Isotype: IgG2b
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: CD3 e
- Target background: The CD3-epsilon polypeptide together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause severe immunodeficiency.
Applications
- Application: FACS ; IP
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061.
