Cat. #151069
Anti-AP2 (a&b) [A6/2/2]
Cat. #: 151069
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Activating Protein 2 (AP-2) alpha and beta forms.
Class: Monoclonal
Application: ELISA ; FACS ; IHC ; IF ; RIA ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Helen Hurst
Institute: Queen Mary University of London
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-AP2 (a&b) [A6/2/2]
- Research fields: Cancer;Tissue-specific biology;Genetics
- Clone: A6/2/2
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; FACS ; IHC ; IF ; RIA ; WB
- Description: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2?ĂÂ may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
- Immunogen: Peptide to C-Terminal of AP-2 Alpha coupled to KLH. PNSHTDNNAKSSDKEEKHRK
- Isotype: IgG1
- Myeloma used: NS0
- Recommended controls: Raji cells or breast carcinomas.
Target Details
- Target: Activating Protein 2 (AP-2) alpha and beta forms.
- Tissue cell line specificity: Raji cells or breast carcinomas.
- Target background: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2? may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
Applications
- Application: ELISA ; FACS ; IHC ; IF ; RIA ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
Related Tools
- Related tools: Anti-cMyc [9E10]
References
- Yang et al. 2005. J Am Soc Nephrol. 16(10):2890-6. PMID: 16107581.
- Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension.
- Gee et al. 1999. J Pathol. 189(4):514-20. PMID: 10629551.
- Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer.
- Batsch et al. 1998. Mol Cell Biol. 18(7):3647-58. PMID: 9632747.
- RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2.
