GST-3X-TDP43_106-175 (DELTARRM1) Vector

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Tool name: GST-3X-TDP43_106-175 (DELTARRM1) Vector
• Alternate name: TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10
• Research fields: Genetics;Neurobiology;Microbiology
• Tool sub type: pGEX
• Backbone size without insert: 4900
• Bacterial resistance: Ampicillin
• Description: Concentration 1mg/ml
• Additional notes: The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). This is a mutant version of TDP-43 that lacks the RRM1 domain and does not bind RNA

Target Details

• Target: TDP43 lacking RRM1

Application Details

• Application notes: Concentration 1mg/ml

References

• Buratti et al. 2001. J Biol Chem. 276(39):36337-43. PMID: 11470789.
• Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9.