#160405

Glucose-6-phosphate Dehydrogenase inhibitor G6PD Small Molecule (Tool Compound)

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Cat. #160405

Glucose-6-phosphate Dehydrogenase inhibitor G6PD Small Molecule (Tool Compound)

Cat. #: 160405

Sub-type: Inhibitor

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Contributor

Inventor: Ian Waddell

Institute: Cancer Research UK Manchester Institute

Tool Details
Handling
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Glucose-6-phosphate Dehydrogenase inhibitor G6PD Small Molecule (Tool Compound)
  • Alternate name: G6PD; G6PD1; Glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase; glucose-6-phosphate dehydrogenase, glucose 6 phosphate dehydrogenase
  • Cancer: Head and neck cancer
  • Cancers detailed: Gastric;Larynx
  • Research fields: Cancer;Cell signaling and signal transduction;Drug development
  • Tool sub type: Inhibitor
  • Description: A selective inhibitor of Glucose-6-phosphate dehydrogenase (G6PD) which demonstrates anti-cancer activity. G6PD is a critical metabolic enzyme involved in the oxidative phase of the pentose phosphate pathway. Chinese hamster ovary cells that are devoid of G6PD display increased sensitivity to radiation and human fibroblasts deficient in G6PD display increased ROS and radiation sensitivity. Clinically, evidence from studies in larynx and gastric cancer suggests that tumours show increased G6PD activity, and this correlates to a poor clinical outcome.
  • Purpose: Inhibitor
  • Selectivity: Inhibitory activity against related targets as % inhibition at given concentration: 6PGDH: 4.7% at 200 ÂľM IDH: 0.9% at 200 ÂľM RET: 4.8% at 100 ÂľM LSD1: 6.3% at 40 ÂľM
  • Solubility: 30-100M in PBS
  • Additional notes: Relevant Indications: Larynx cancer, Gastric cancer

Handling

  • Shipping conditions: Dry Ice

Target Details

  • Ic50: 1.0 uM

References

  • Hamilton et al. 2012. J Med Chem. 55(9):4431-45. PMID: 22506561.
  • Hitchin et al. 2012. Tetrahedron Letters. 53:2868-72