1. CS-5d (9-(Cyclopropylmethyl)-N6-(3;4-difluorophenyl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-9H-purine-2;6-diamine) 2. CS-5c (9-(Cyclopropylmethyl)-N6-(3-fluorophenyl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-9H-purine-2;6-diamine)

Cat. #160518

CS-5c Bcr-Abl and Btk small molecule kinase inhibitors

Cat. #: 160518

Sub-type: Inhibitor

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Contributor

Inventor: Cristian Salas

Institute: Pontificia Universidad Catolica de Chile

Tool Details

Handling

Target Details

Related Tools

References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

Tool name: CS-5c Bcr-Abl and Btk small molecule kinase inhibitors
Cancer: Blood cancer
Cancers detailed: Leukemia
Research fields: Cancer;Drug development;Other
Molecular formula: C26H29FN8
Tool sub type: Inhibitor
Primary target: Bcr-Abl and Btk kinases
Description: This compound inhibits in nanomolar scale for Bcr-Abl (40 nM) and sub-micromolar scale for Btk kinases (0,58 M), both are related to the genesis and progression of myeloid and lymphoid leukaemia, respectively
Purpose: Inhibitor
Iupac: 9-(Cyclopropylmethyl)-N6-(3-fluorophenyl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-9H-purine-2,6-diamine
Molecular weight: 472.5605
Solubility: DMSO

Handling

Purity: 472.5605 g/mol
Storage conditions: Away from UV light
Shipping conditions: Dry Ice

Target Details

Primary target: Bcr-Abl and Btk kinases

Related Tools

Related tools: CS-5d Bcr-Abl and Btk small molecule kinase inhibitors

References

Bertrand et al. 2020. Bioorg Chem. 94:103361. PMID: 31699386.