Cat. #161687
Carbazole derivative HV-107
Cat. #: 161687
Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42
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Contributor
Inventor: Cornelis Vlaar
Institute: University of Puerto Rico
Primary Citation: Vlaar et al. Bioorg Med Chem. 26(4): 884-890 PMID: 29358027
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Carbazole derivative HV-107
- Primary target: Rac
- Secondary targets: Rac 1
- Description: Carbazole derivative HV-107 is a highly potent novel anti-cancer and anti-metastatic carbazole derivative. Carbozole derivatives based on EHop-016 generated to mimic the ‘U-shaped’ conformation adopted by EHop-016 as it binds Rac1.
- Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42
- Purpose: Designed to mimic the 'U-shaped' conformation adopted by EHop-016 as it binds Rac1
Target Details
- Primary target: Rac
- Secondary targets: Rac 1
- Ic50: 250 nM
Application Details
- Application: Cancer research, anti-metastatic therapeutics development, potential treatment for other hyperproliferative diseases associated with Rac1 and Cdc42
References
- Vlaar et al. Bioorg Med Chem. 26(4): 884-890 PMID: 29358027
