#153526

VIPER Peptide

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Cat. #153526

VIPER Peptide

Cat. #: 153526

Sub-type: Synthetic Peptide

Availability: Please enquire for quantities and pricing

Target: Toll-like receptor 4 (TLR4)

Function: Marker

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Andrew Bowie

Institute: Trinity College Dublin

Tool Details
Handling
Target Details
Application Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: VIPER Peptide
  • Research fields: Drug development;Immunology;Microbiology
  • Tool sub type: Synthetic Peptide
  • Sequence: KYSFKLILAEY
  • Cellular tissue localisation: Vaccinia virus protein A46
  • Source: Synthetic
  • Target: Toll-like receptor 4 (TLR4)
  • Description: Overview: Toll-like receptor 4 (TLR4) recognises pathogens leading to activation of the immune response, but also contributes to the development of a number of autoimmune and inammatory diseases. As such, it has become a new target for drug development. Over millennia, viruses have optimised their ability to inhibit the immune response. Thus the Vaccinia virus protein A46 displays a remarkable ability to inhibit TLR4 function. This viral know-how has been exploited to develop an 11-amino acid peptide from A46, termed viral inhibitor peptide of TLR4, or VIPER, which, when fused to a cell-penetrating delivery sequence, potently and specically inhibits TLR4-mediated responses in vitro and in vivo. Advantages: VIPER most likely represents a surface of A46 that has been optimised by the virus to potently inhibit TLR4, so has already been through a ‘naturally occurring drug development programme'. VIPER is more effective at inhibiting TLR4 than other currently used peptide inhibitors of TLR4, in that it is more specic, more potent, less toxic, and is effective in primary human cells. Possible Applications: Experimental tool for exploring TLR4 complex formation and signalling, for analysing the role of TLR4 in in vivo models of disease and for predicting a role for Mal or TRAM in a disease process. Development as a therapeutic agent, for example by developing it into a peptidomimetic. Analysis of surfaces on Mal and TRAM targeted by VIPER as drugable sites during inammation.
  • Function: Marker
  • Additional notes: VIPER has been validated preclinically for ecacy, with ongoing work being carried out in disease models. US patent 8,722,052

Handling

  • Shipping conditions: Dry Ice

Target Details

  • Target: Toll-like receptor 4 (TLR4)

Application Details

  • Application notes: VIPER has been validated preclinically for ecacy, with ongoing work being carried out in disease models. US patent 8,722,052

References

  • Lysakova-Devine et al. 2010. J Immunol. 185(7):4261-71. PMID: 20802145.
  • Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.