K5R2b Null Mouse

A mouse model with epidermal FgfR 2b expression knocked out. The mouse lives a normal life span but has altered hair morphology.

Contributors

Inventor Institute
Clive Dickson Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151561
Cancer types: Gastric cancer
Research Fields: Cancer;Cell signaling and signal transduction;Genetics;Immunology
Target: Fibroblast growth factor receptor 2 isoform IIIb (FGFR2IIIb)
Model: Knock-Out
Phenotype: Skin abnormalities, Tumourigenesis
Product description: A mouse model with epidermal FgfR 2b expression knocked out. The mouse lives a normal life span but has altered hair morphology. It has a tendency to develop skin papillomas spontaneously and development of these can be accelerated greatly by use of a carcinogen.
Conditional: Yes
Conditional description: Fgfr2bflox/flox mouse crossed with K5-Cre mouse (tissue-specific Cre expression in skin) giving tissue-specific knockout of FGFR2 IIIb isoform in skin.
Genetic background: Homozygous Fgfr2bflox/flox mice, carrying a loxP flanked IIIb exon of FGFR2, were crossed with male heterozygous K5-Cre mice, carrying Cre recombinase transgene under control of the Keratin-5 promoter. Mice were maintained on a mixed 129/C57BL6 background.
Production details: Homozygous Fgfr2bflox/flox mice, carrying a loxP flanked IIIb exon of FGFR2, were crossed with male heterozygous K5-Cre mice, carrying Cre recombinase transgene under control of the Keratin-5 promoter. Mice were maintained on a mixed 129/C57BL6 background.
Additional notes: The K5-R2b-null mouse is an ideal tool in the study of the tumour suppressive role of the FGFR2 IIIb isoform in skin tumourigenesis.Skin tumours develop in K5-R2b-null mice following two-step carcinogen treatment with DMBA and TPA.
Shipping conditions: Embryo/Spermatoza- Dry Ice

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