Cat. #151444
InvEE Mouse
Cat. #: 151444
Sub-type: Mouse
Availability: 6-8 weeks
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Fiona Watt
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: InvEE Mouse
- Research fields: Cell signaling and signal transduction;Genetics
- Tool sub type: Mouse
- Conditional: Yes
- Conditional description: Conditional expression of MEK1 under involucrin promoter giving tissue-specific suprabasal epidermal expression.
- Description: A transgenic mouse expressing constitutively active MEK 1 in the epidermis. The mouse displays many phenotypes associated with psoriasis including abnormal keratinocyte differentation, hyperproliferation of keratinocytes and infiltration of inflammatory elements. Disease model for psoriasis; in vivo study of constituitively active murine MEK1 mutant (S217E/S221E) in skin.
- Genetic background: An involucrin - MEK1 transgene expression construct was injected into male pronucleus of fertilized F1 hybrid CBAxC57Bl/6 embryos. Transgene-positive mice were mated with wildtype F1 CBAxC57BL/6 to generate founder lines.
- Production details: An involucrin - MEK1 transgene expression construct was injected into male pronucleus of fertilized F1 hybrid CBAxC57Bl/6 embryos. Transgene-positive mice were mated with wildtype F1 CBAxC57BL/6 to generate founder lines.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: MEK1
References
- Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.
- Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.
