Double Floxed Fbxw7/FoxM1

FoxM1 is plays a key role in the cell cycle as endogenous expression peaks at the S and G2/M phases, crucial for mitotic division

Contributors

Inventor Institute
Abdolrahman Shams-Nateri University of Nottingham
Cat. #: 153594
Cancer types: Digestive / Gastrointestinal cancer
Research Fields: Cancer;Drug development;Metabolism
Target: Fbxw7 and foxM1
Model: Conditional KO
Zygosity: Homozygous
Strain: C57BL/6
Alternate name: F-box/WD repeat–containing protein 7, CDC4, Sel1, Ago, Fbw7, SCF, Skp1/Cullin/F-box protein, E3 ubiquitin ligase complex,FBW6, FBX3, FBXO3, FBXW6, SEL-1, hAgo, hCdc4, FOXM1, FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT, forkhead box M1
Product description: FoxM1 is plays a key role in the cell cycle as endogenous expression peaks at the S and G2/M phases, crucial for mitotic division. Recent studies have shown that FOXM1 regulates expression of a large array of G2/M-specific genes which play a crucial role in maintenance of genomic stability and chromosomal segregation. There are 3 known isoforms of FoxM1, A, B & C and it is a known human proto-oncogene, involved in basal cell carcinoma. Fbxw7 is a member of the F-box protein family, characterised by a motif of approximately 40 amino acids called the F-box. These proteins constitute one of the four subunits of ubiquitin protein ligase complex called SKP1-cullin-F-box and function in phosphorylation-dependent ubiquitination. Fbxw7 specifically protein contains 7 tandem solenoid protein domains also know as WD40 repeats. Fbwx7 binds directly to cyclin E and probably targets it for ubiquitin-mediated degradation.
Conditional: Yes
Conditional description: Requires expression of Cre recombinase to mediate excision of the lox P sites generating non-functional Fbxw7 and foxM1 proteins
Production details: This model was created by interbreeding the floxed-Fbxw7 mouse with a floxed-FoxM1 mouse (for floxed-FoxM1 mouse see references).
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Yoshida et al. 2007. Gastroenterology. 132(4):1420-31. PMID: 17408638.

The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer.

Wang et al. 2002. Proc Natl Acad Sci U S A. 99(26):16881-6. PMID: 12482952.

The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration.

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