SK-UT-1 Cell Line

This cell line has little or no phosphorylated retinoblastoma protein compared to the SK-UT-1B cells. SK-UT-1 cells are capable of forming tumours when inoculated in immunocompromised mice.

Contributors

Inventor Institute
Lloyd J. Old, Germaine Trempe Memorial Sloan-Kettering Cancer Center (MSK)
Cat. #: 161923
Cancer types: Gynaecologic cancer
Organism: Human
Tissue: Uterus
Gender: Female
Model: Tumourigenic
Morphology: Epithelial
Growth properties: Adherent
Cancer Types In Detail: Ovarian
Primary citation: Fogh et al. 1977. Journal of the National Cancer Institute. 59: 221-226. PMID: 327080.
Product description: This cell line has little or no phosphorylated retinoblastoma protein compared to the SK-UT-1B cells. SK-UT-1 cells are capable of forming tumours when inoculated in immunocompromised mice.
Gender: Female
Additional notes: The cells form spindle cell sarcomas.
Model description: Tumourigenic in nude mice
disease: Ovarian cancer
Products or characteristics of interest: Karyotype: (P8) hypodiploid to hyperdiploid. Isoenzymes: AK-1, 1; ES-D, 1; G6PD, B; Me-2, 1-2; PGM1, 1; PGM3, 1
Storage conditions: Vapor phase of liquid nitrogen
Shipping conditions: Dry Ice
Growth medium: EMEM supplemented with FBS to a final concentration of 10%; formulated for use with a 5% CO2 in air atmosphere
Temperature: 37° C
Atmosphere: 5% CO2 in air
Storage medium: Complete growth medium supplemented with 5% (v/v) DMSO
Biosafety level: 1
References:

Ganiatsas et al. 2001. Oncogene. 20: 3641-50. PMID: 11439327.

Li et al. 2013. International Journal of Gynecological Cancer. 23: 803-808. PMID: 23532091.

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