#153294

Sdhb fl/fl Cell Line

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Cat. #153294

Sdhb fl/fl Cell Line

Cat. #: 153294

Unit size: 1x10^6 cells / vial

Availability: 3-4 weeks

Organism: Mouse

Tissue: Kidney

Disease: Cancer

Model: Conditional KO

£575.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Eyal Gottlieb

Institute: Cancer Research UK, Glasgow: The Beatson Institute

Tool Details
Target Details
Handling
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Sdhb fl/fl Cell Line
  • Alternate name: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
  • Research fields: Cancer;Drug development;Metabolism
  • Organism: Mouse
  • Tissue: Kidney
  • Disease: Cancer
  • Model: Conditional KO
  • Conditional: Yes
  • Conditional description: Deletion of succinate dehydrogenase can be achieved by intracellular expression of Cre recombinase
  • Description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation.
  • Biosafety level: 1
  • Cellosaurus id: CVCL_HG11

Target Details

  • Target: Succinate dehydrogenase

Handling

  • Format: Frozen
  • Unit size: 1x10^6 cells / vial
  • Shipping conditions: Dry ice
  • Storage conditions: Liquid Nitrogen
  • Mycoplasma free: Yes

Related Tools

  • Related tools: Sdhb -/- CL 5 Cell Line ; Sdhb -/- CL 7 Cell Line ; SDHB Floxed Mouse

References

  • Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
  • Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.