Cat. #156407
R-3327-3.1 cell line
Cat. #: 156407
Unit size: 1x10^6 cells / vial
Availability: 10-12 weeks
Disease: Cancer
Model: Cancer Model
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: John Isaacs
Institute: Johns Hopkins University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: R-3327-3.1 cell line
- Research fields: Cancer;Drug development
- Disease: Cancer
- Model: Cancer Model
- Description: AT-3 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat in 1961. R3327 has been maintained by continuous serial passage in rats for many years. Following subcutaneous transplantation in syngeneic male rats, AT-3 forms solid sheets of malignant cells with no indication of glandular function. AT-3.1 tumors grow continuously with a doubling time of 1.5-1.8 days regardless of the androgen status of the host and exhibit a high rate of metastasis to the lung and lymph nodes (>75% of rats inoculated sub-cutaneously develop distant metastases). The AT-3 subline can be used to study the effects of various types of cancer therapies on prostate cells. Together AT-3 and the related Dunning sublines also provide a valuable model for studying prostate malignancies both in vitro and in vivo.
- Cellosaurus id: CVCL_3570
Target Details
- Target: Gives rise to malignant cells with a high rate of metastasis in lymph nodes and lung
Handling
- Format: Frozen
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
References
- Ichikawa et al. 1992. Cancer Res. 52(12):3486-90. PMID: 1596907.
- Ichikawa et al. 1991. Cancer Res. 51(14):3788-92. PMID: 2065333.
