Melan-sut2 cell line

Immortal melanocytes derived from Slc7a11sut/Slc7a11sut Ink4aArf -/- B6/C3H/HeSnJ mice

Contributors

Inventor Institute
Elena Sviderskaya St. George's University London
Cat. #: 162039
Organism: Mouse
Tissue: Skin
Model: Immortalised non-cancerous cell lines
Morphology: Small, oval-fusiform
Product description: The melan-sut1, -sut2 and -sut3 cell lines are immortal melanocytes derived from Slc7a11sut/Slc7a11sut Ink4aArf -/- B6/C3H/HeSnJ mice. The Slc7a11 locus encodes a cysteine antiporter and regulates pheomelanogenesis. The sut mouse (Slc7a11 mutant) reduces pheomelanogenesis. In humans SLC7A11 expression may be elevated in melanoma patients. These cells may be useful for the study of pigment cell biology and for the role of Slc7a11 in melanoma.
Storage conditions: liquid N2

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