LF2 Cell Line

LF2 Cell Line: a germ-line competent embryonic stem cell line that inactivates one of its X chromosomes upon retinoic acid treatment.

Contributors

Inventor Institute
Jennifer Nichols University of Oxford
Cat. #: 152568
Unit size: 1×10^6 cells / vial
Research Fields: Genetics;Stem cell biology
Organism: Mouse
Tissue: Embryo
Product description: The LF2 mouse embryonic stem cell line is a germ-line competent embryonic stem cell line that inactivates one of its X chromosomes upon retinoic acid treatment. Embryonic stem cells provide a powerful system for the experimental analysis of mammalian development. Their genetic manipulation allows the introduction of defined modifications into the mouse germ-line, whilst in culture they constitute both an assay system for, and a potential source of, embryonic regulatory factors.
Conditional: No
Cellosaurus ID: CVCL_AS05
Format: Frozen
Shipping conditions: Dry ice
Growth medium: Embryonic bodies were formed by growing cells in low adherence dishes in DMEM+FBS for 10 days.
References:

Evans et al. Development 110, 1341-1348 (1990).

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