TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin.
| Institute |
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| The Institute of Cancer Research |
| Cat. #: | 151322 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy;Cancer;Cell biology |
| Application: | IP ; WB |
| Target: | T-complex polypeptide 1 (TCP1) |
| Reactivity: | Mouse |
| Clone: | 84a (CTA-184) |
| Host: | Rat |
| Class: | Monoclonal |
| Product description: | TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 80 kDa |
| Immunogen: | C-terminal half of the full length murine TCP protein |
| Myeloma used: | Y3.AG.1.2.3 |
| Target background: | TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Sternlicht et al. 1993. Proc Natl Acad Sci U S A. 90(20):9422-6. PMID: 8105476. The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo. Harrison-Lavoie et al. 1993. EMBO J. 12(7):2847-53. PMID: 8335000. A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins. Willison et al. 1989. Cell. 57(4):621-32. PMID: 2655925. The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes. |
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