Anti-Tap63 [TAp63-4.1]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-Tap63 [TAp63-4.1]
• Clone: TAp63-4.1
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 76 kD
• Reactivity: Human ; mouse ; rat
• Host: Mouse
• Description: Antibody created to detect the TA isoform of p63 (TAp63) with tumour suppressor role and differentiate from the deltaN (deltaNp63) isoforms of the same protein. Binding specificity: epitope mapping using phage disply identified the epitope LSDPxW for all clones.
• Immunogen: Recombinant human TAp63delta
• Isotype: IgG2a kappa
• Production details: B cell donor: Splenocytes from mouse immunised with recombinant TAp63? , Fusion partner: SP2

Target Details

• Target: transactivation domain of tumour protein p63
• Molecular weight: 76 kD
• Target background: p63 is a transcription factor of the p53 gene family, encoded by the TP63 gene located at chromosome 3q28. p63 exists as N-terminal isoforms that either contain (TAp63) or lack (deltaNp63) the p53-like transactivation domain at the N-terminus. C-terminal isoforms are produced by alternative splicing of 3' exons. TAp63 is involved in germ cell maintenance and myocyte differentiation, and is expressed in some lymphocytes and lymphomas/leukaemias.
• Epitope sequence: LSDPxW sequence of tumour protein p63 (TA isoform)

Handling

• Format: Liquid

References

• Orzol et al. 2016. Tumour Biol. Aug:37(8):10133-40. PMID: 26825981
• Galoczova et al. 2021. Virchows Arch. Apr:478(4):627-636. PMID: 33037932
• Pokorna et al. 2022. Front Oncol. Jul 14:12:924354. PMID: 35912167