#151541

Anti-RAET1E [RAET1E 50/3]

Cat. #151541

Anti-RAET1E [RAET1E 50/3]

Cat. #: 151541

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: RAET1E

Class: Monoclonal

Application: ELISA ; FACS ; IF ; IP ; Fn ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Institute: University of Cambridge

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-RAET1E [RAET1E 50/3]
  • Research fields: Immunology
  • Clone: RAET1E 50/3
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: ELISA ; FACS ; IF ; IP ; Fn ; WB
  • Description: RAET1E (Retinoic Acid Early Transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a functional ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines.
  • Immunogen: Recombinant His-tagged protein to human extra-cellular domain of RAET1E, grown in E.coli
  • Isotype: IgG2b
  • Recommended controls: Stable RAET1E cell line

Target Details

  • Target: RAET1E
  • Tissue cell line specificity: Stable RAET1E cell line
  • Target background: RAET1E (Retinoic Acid Early Transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a Fn ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines.

Applications

  • Application: ELISA ; FACS ; IF ; IP ; Fn ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Cao et al. 2007. J Biol Chem. 282(26):18922-8. PMID: 17470428.
  • RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity.
  • Bacon et al. 2004. J Immunol. 173(2):1078-84. PMID: 15240696.
  • Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.
  • Chalupny et al. 2003. Biochem Biophys Res Commun. 305(1):129-35. PMID: 12732206.
  • ULBP4 is a novel ligand for human NKG2D.