PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104.
| Inventor | Institute |
|---|---|
| Lionel Crawford | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151143 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy;Cancer;Cell biology;Genetics |
| Application: | IHC ; IP |
| Target: | p53 |
| Reactivity: | Human |
| Clone: | Pab 1104 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796. |
| Product description: | PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Molecular weight: | 53 kDa |
| Immunogen: | A slice of gel containing p53 homogenised in PBS. The p53 was extracted from the human SV40-transformed fibroblast cell line SV80 and purified by immunoprecipitation and SDS gel electrophoresis. |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Nayak et al. 2007. Cancer Res. 67(12):5831-9. PMID: 17575151. Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs. Leppard et al. 1984. J Virol. 50(2):457-64. PMID: 6323746. An oligomeric form of simian virus 40 large T-antigen is immunologically related to the cellular tumor antigen p53. Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796. Monoclonal antibodies displaying a novel spe… |
|---|
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151015 | Anti-CyclinA [E70.1] |
Key Info
Anti-CyclinA [E70.1]
|
View Tool | |||||||||||||||||||
| 151016 | Anti-CyclinA [E72.1] |
Key Info
Anti-CyclinA [E72.1]
|
View Tool | |||||||||||||||||||
| 151025 | Anti-Vascular endothelium [10] |
Key Info
Anti-Vascular endothelium [10]
|
View Tool | |||||||||||||||||||
| 151039 | Anti-Integrin aVb3 [23C6] |
Key Info
Anti-Integrin aVb3 [23C6]
|
View Tool | |||||||||||||||||||
| 151020 | Anti-CyclinB1 [V143.1] |
Key Info
Anti-CyclinB1 [V143.1]
|
View Tool | |||||||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.