#151143

Anti-p53 [Pab 1104]

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Cat. #151143

Anti-p53 [Pab 1104]

Cat. #: 151143

Sub-type: Primary antibody

Unit size: 100 ug

Target: p53

Class: Monoclonal

Application: IHC ; IP

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Lionel Crawford

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Primary Citation: Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796.

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-p53 [Pab 1104]
  • Cancer: Other
  • Cancers detailed: Broadly Applicable
  • Research fields: Apoptosis and autophagy;Cancer;Cell biology;Genetics
  • Clone: Pab 1104
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 53 kDa
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; IP
  • Description: PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104.
  • Immunogen: A slice of gel containing p53 homogenised in PBS. The p53 was extracted from the human SV40-transformed fibroblast cell line SV80 and purified by immunoprecipitation and SDS gel electrophoresis.
  • Isotype: IgM
  • Myeloma used: P3/NS1/1-Ag4.1
  • Recommended controls: MDA-MB-231 cell line

Target Details

  • Target: p53
  • Molecular weight: 53 kDa
  • Tissue cell line specificity: MDA-MB-231 cell line
  • Target background: PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104.

Applications

  • Application: IHC ; IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Nayak et al. 2007. Cancer Res. 67(12):5831-9. PMID: 17575151.
  • Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs.
  • Leppard et al. 1984. J Virol. 50(2):457-64. PMID: 6323746.
  • An oligomeric form of simian virus 40 large T-antigen is immunologically related to the cellular tumor antigen p53.
  • Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796.
  • Monoclonal antibodies displaying a novel spe...