AC8.3 can be used as a detection system for rapidly dividing cells and is recommended for use in tissue culture.
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151194 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | ELISA ; FACS ; IHC ; IF ; IP ; WB |
| Target: | p21 |
| Reactivity: | Human |
| Clone: | AC8.3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Cyclin-Dependent Kinase Inhibitor 1A; CDK-Interacting Protein 1; CDKN1; CAP2; MDA-6; CIP1; SDI1; WAF1; P21; Melanoma Differentiation Associated Protein 6; Wild-Type P53-Activated Fragment 1; CDK-Interaction Protein 1; DNA Synthesis Inhibitor; P21CIP1; MDA6; PIC1 |
|---|---|
| Product description: | AC8.3 can be used as a detection system for rapidly dividing cells and is recommended for use in tissue culture. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | His-tagged human p21 expressed in bacleva virus. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Cell cycle progression is regulated by cyclins and their cognate Cdks. p21 (WAF1/CIP1) inhibits the activity of each member of the cyclin/Cdk family, and overexpression of this protein inhibits the proliferation of mammalian cells. The expression of p21 is inducible by a wide range of stress stimuli. p21 is tightly regulated at the transcriptional level by p53, and probably serves as the effector of p53 cell cycle control. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Xu et al. 2010. Biol Pharm Bull. 33(5):743-51. PMID: 20460749. Petrides et al. 2008. J Comp Neurol. 507(5):1653-62. PMID: 18241050. |
|---|
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151024 | Anti-Hairy [1/24] |
Key Info
Anti-Hairy [1/24]
|
View Tool | |||||||||||||||||||
| 151027 | Anti-HSVICP8 [10A3] |
Key Info
Anti-HSVICP8 [10A3]
|
View Tool | |||||||||||||||||||
| 151029 | Anti-HSVICP8 [11E2] |
Key Info
Anti-HSVICP8 [11E2]
|
View Tool | |||||||||||||||||||
| 151033 | Anti-HSVUL42 [13C9] |
Key Info
Anti-HSVUL42 [13C9]
|
View Tool | |||||||||||||||||||
| 151018 | Anti-Mos [R38.1] |
Key Info
Anti-Mos [R38.1]
|
View Tool | |||||||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.