Anti-Omentin [3G1B3]

Monoclonal antibody which detects omentin, linked to diabetes.

Contributors

Institute
University of Maryland
Cat. #: 153990
Unit size: 100 ug
Research Fields: Immunology;Metabolism;Microbiology;Tissue-specific biology
Application: IP ; WB
Target: Omentin
Reactivity: Human ; Mouse ; Rat
Host: Mouse
Class: Monoclonal
Alternate name: Intelectin-1, ITLN1, hIntL-1
Product description: Monoclonal antibody which detects omentin, linked to diabetes. Background and Research Application: Omentin (human intelectin-1) is a secreted glycoprotein involved in the innate immune system as well as enhancing insulin-stimulated glucose uptake. Highly expressed in small intestine and adipose tissue and present at lower levels in testis, heart, pancreas, colon and skeletal muscle, intelectin-1 exists as a disulphide-linked homotrimer that functions to enhance insulin-stimulated glucose uptake and is also thought to participate in host defence against microorganisms. Serum levels of omentin are negatively correlated with obesity, suggesting a role in diabetes. More recently, omentin has been shown to interact with glycans on pathogenic bacteria.
Conjugation: Unconjugated
Isotype: IgG
Molecular weight: 120 kDa (trimer), 37 kDa (monomer)
Immunogen: Q8WWA0
Immunogen Uniprot ID: Q8WWA0
Target background: Monoclonal antibody which detects omentin, linked to diabetes. Background and Research Application Omentin (human intelectin-1) is a secreted glycoprotein involved in the innate immune system as well as enhancing insulin-stimulated glucose uptake. Highly expressed in small intestine and adipose tissue and present at lower levels in testis, heart, pancreas, colon and skeletal muscle, intelectin-1 exists as a disulphide-linked homotrimer that functions to enhance insulin-stimulated glucose uptake and is also thought to participate in host defence against microorganisms. Serum levels of omentin are negatively correlated with obesity, suggesting a role in diabetes. More recently, omentin has been shown to interact with glycans on pathogenic bacteria.
Format: Liquid
Shipping conditions: Dry ice
References:

Yang et al. 2006. Am J Physiol Endocrinol Metab. 290(6):E1253-61. PMID: 16531507.

Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.

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