Anti-NCAM [ERIC-1]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-NCAM [ERIC-1]
• Alternate name: Neural Cell Adhesion Molecule; NCAM; CD56 Antigen; MSK39
• Cancer: Neurological cancer;Genitourinary cancer
• Cancers detailed: Brain;Kidney;Broadly Applicable
• Research fields: Cell biology;Cell signaling and signal transduction;Neurobiology;Stem cell biology
• Clone: ERIC-1
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 180 kDa, 140 kDa, 120 kDa
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB
• Description: NCAM, also known as CD56, is a homophillic binding glycoprotein present on a variety of neural cells including neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system.
• Immunogen: Retinoblastoma tissue membrane fraction
• Isotype: IgG1
• Myeloma used: P3X63Ag8.653
• Recommended controls: Neuroblastome

Target Details

• Target: Neural Cell Adhesion Molecule (NCAM; CD56)
• Molecular weight: 180 kDa, 140 kDa, 120 kDa
• Tissue cell line specificity: Neuroblastome
• Target background: NCAM, also known as CD56, is a homophillic binding glycoprotein present on a variety of neural cells including neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system.

Applications

• Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

References

• Markovic-Lipkovski et al. 2015. PLoS One. 10(9):e0137028. PMID: 26327314.
• Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.
• Klehr et al. 2009. J Immunother. 32(5):442-51. PMID: 19609236.
• The novel chimeric anti-NCAM (neural cell adhesion molecule) antibody ch.MK1 displays antitumor activity in SCID mice but does not activate complement-dependent cytolysis (CDC).
• Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935.
• Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.
• Blaheta et al. 2004. Neoplasia. 6(4):323-31. PMID: 15256054.
• Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness.
• Jensen et al. 2003. Clin Exp Immunol. 134(2):253-63. PMID: 14616785.
• The bi-specific CD3 x NCAM antibody: a model to preactivate T cells prior to tumour cell lysis.
• Gerardy-Schahn et al. 1994. Int J Cancer Suppl. 8:38-42. PMID: 7515028.
• Hot spots of antigenicity in the neural cell adhesion molecule NCAM.
• Phimister et al. 1991. J Clin Pathol. 44(7):580-5. PMID: 1856291.
• Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.
• Frost et al. 1991. Neuropathol Appl Neurobiol. 17(3):207-17. PMID: 1891065.
• Expression of alternative isoforms of the neural cell adhesion molecule (NCAM) on normal brain and a variety of brain tumours.
• Bourne et al. 1991. J Neurooncol. 10(2):111-9. PMID: 1895159.
• A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm.