Anti-Keratin10 [LH2]

LH2 recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10).

Contributors

Inventor Institute
Irene Leigh Queen Mary University of London
Cat. #: 151115
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: FACS ; IHC ; IF ; IP ; WB
Target: Keratin 10
Reactivity: Human ; Mouse
Clone: LH2
Host: Mouse
Class: Monoclonal
Alternate name: BCIE, BIE, EHK, Keratin Type I Cytoskeletal 1, KRT1Human Entrez Gene ID 3858 Human SwissProt P13645 Human Unigene 99936 Human Gene Symbol KRT1Human Chromosome Location 17q21.2
Product description: LH2 recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10).
Conjugation: Unconjugated
Isotype: IgG1 kappa
Molecular weight: 56.5kDa
Immunogen: extract of skin from psoriasis patient
Myeloma used: Sp2/0-Ag14
Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 10 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Keratin 10 is a suprabasal marker of differentiation in stratified squamous epith…
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Lehman et al. 2015. Am J Pathol. 185(1):240-51. PMID: 25529795.

Barrott et al. 2011. Proc Natl Acad Sci U S A. 108(31):12752-7. PMID: 21768372.

Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.

Porter et al. 2000. Lab Invest. 80(11):1701-10. PMID: 11092530.

K15 expression implies lateral differentiation within stratified epithelial basal cells.

Reichelt et al. 1997. J Cell Sci. 110 ( Pt 18):2175-86…

Images

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Formalin-fixed; paraffin-embedded human Bladder Carcinoma stained with Cytokeratin 10 Monoclonal Antibody (LH2).

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