#151115

Anti-Keratin10 [LH2]

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Cat. #151115

Anti-Keratin10 [LH2]

Cat. #: 151115

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: Keratin 10

Class: Monoclonal

Application: FACS ; IHC ; IF ; IP ; WB

Reactivity: Human ; Mouse

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Irene Leigh

Institute: Queen Mary University of London

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Keratin10 [LH2]
  • Alternate name: BCIE, BIE, EHK, Keratin Type I Cytoskeletal 1, KRT1Human Entrez Gene ID 3858 Human SwissProt P13645 Human Unigene 99936 Human Gene Symbol KRT1Human Chromosome Location 17q21.2
  • Research fields: Cell signaling and signal transduction
  • Clone: LH2
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Purpose: Marker
  • Conjugation: Unconjugated
  • Molecular weight: 56.5kDa
  • Strain: Balb/c
  • Reactivity: Human ; Mouse
  • Host: Mouse
  • Application: FACS ; IHC ; IF ; IP ; WB
  • Description: LH2 recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10).
  • Immunogen: extract of skin from psoriasis patient
  • Isotype: IgG1 kappa
  • Myeloma used: Sp2/0-Ag14
  • Recommended controls: Extract of skin from psoriasis patient

Target Details

  • Target: Keratin 10
  • Molecular weight: 56.5kDa
  • Tissue cell line specificity: Mouse
  • Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 10 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Keratin 10 is a suprabasal marker of differentiation in stratified squamous epith...

Applications

  • Application: FACS ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Lehman et al. 2015. Am J Pathol. 185(1):240-51. PMID: 25529795.
  • Barrott et al. 2011. Proc Natl Acad Sci U S A. 108(31):12752-7. PMID: 21768372.
  • Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome.
  • Porter et al. 2000. Lab Invest. 80(11):1701-10. PMID: 11092530.
  • K15 expression implies lateral differentiation within stratified epithelial basal cells.
  • Reichelt et al. 1997. J Cell Sci. 110 ( Pt 18):2175-86...