#152683

Anti-Keratin 1 [LL017]

Cat. #152683

Anti-Keratin 1 [LL017]

Cat. #: 152683

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: Keratin 1, Cytokeratin 1

Class: Monoclonal

Application: IHC ; IHC

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Irene Leigh

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-Keratin 1 [LL017]
  • Research fields: Cell signaling and signal transduction
  • Clone: LL017
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; IHC
  • Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Mutations in keratin 1 causes epidermolytic hyperkeratosis. LL017 does not react with any tumour tissue regardless of histological classification.
  • Immunogen: Synthetic peptide - VSTTYSGVTR
  • Isotype: IgM
  • Myeloma used: Sp2/0-Ag14

Target Details

  • Target: Keratin 1, Cytokeratin 1
  • Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Mutations in keratin 1 causes epidermolytic hyperkeratosis. LL017 does not react with any tumour tissue regardless of histological classification.

Applications

  • Application: IHC ; IHC

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • de Berker et al. 1995. Exp Dermatol. 4(6):350-6. PMID: 8608342.
  • Keratin expression in discoid lupus erythematosus.
  • Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603.
  • Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.
  • Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396.
  • Keratin expression in basal cell carcinomas.
  • Ishida-Yamamoto et al. 1991. J Invest Dermatol. 97(6):959-68. PMID: 1721080.
  • Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14.