Cat. #161583
Anti-Integrin alpha3 (CD49c) monoclonal antibody [KU44.22B]
Cat. #: 161583
Sub-type: Primary antibody
Target: Integrin alpha3
Class: Monoclonal
Application: ELISA, IHC, IF, IP, WB, FACS
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Helmout Modjtahedi
Institute: Kingston University
Primary Citation: Arias-Pinilla et al. 2020. Sci Rep. 10(1):537. PMID: 31953437
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-Integrin alpha3 (CD49c) monoclonal antibody [KU44.22B]
- Cancer: Pancreatic cancer
- Cancers detailed: Pancreatic cancer
- Research fields: Cancer
- Clone: KU44.22B
- Tool sub type: Primary antibody
- Class: Monoclonal
- Molecular weight: 110 kDa
- Reactivity: Human
- Host: Mouse
- Disease: Cancer
- Application: ELISA, IHC, IF, IP, WB, FACS
- Description: MAb KU44.22B inhibits the growth in vitro of Capan-2 cancer cells, increases migration of BxPC-3 and CFPAC-1 cancer cell lines and induces receptor downregulation and internalisation
- Immunogen: CFPAC-1 cell line
- Isotype: IgG1 kappa
Target Details
- Target: Integrin alpha3
- Target alternate names: CD49c
- Molecular weight: 110 kDa
- Target background: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.
Applications
- Application: ELISA, IHC, IF, IP, WB, FACS
Related Tools
- Related tools: KU43.13A monoclonal antibody
References
- Arias-Pinilla et al. 2020. Sci Rep. 10(1):537. PMID: 31953437
