Anti-Cytochrome P450 4V2 [M29-P3B10]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-Cytochrome P450 4V2 [M29-P3B10]
• Alternate name: Cytochrome P45; Family 4; Subfamily V; Polypeptide 2; Docosahexaenoic Acid Omega-Hydroxylase CYP4V2; CYP4AH1; BCD
• Research fields: Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology
• Clone: M29-P3B10
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: ELISA ; IHC ; WB
• Description: Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4V2 catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. CYP4V2 may have a role in fatty acid and steroid metabolism in the eye and its mutations are associated with Bietti's crystalline dystrophy (BCD) and retinitis pigmentosas.
• Immunogen: Peptide sequence KREELGLEGQ (amino acids 495 504)
• Isotype: IgG1 kappa
• Myeloma used: P3X63Ag8.653
• Recommended controls: ELISA- Peptide immunogen; Western Blot- Human liver microsomes; IHC- Human liver

Target Details

• Target: Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2)
• Tissue cell line specificity: ELISA- Peptide immunogen; Western Blot- Human liver microsomes; IHC- Human liver
• Target background: Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4V2 catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. CYP4V2 may have a role in fatty acid and steroid metabolism in the eye and its mutations are associated with Bietti's crystalline dystrophy (BCD) and retinitis pigmentosas.

Applications

• Application: ELISA ; IHC ; WB

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Alnabulsi et al. 2017. Br J Cancer. :. PMID: 28557975.
• The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance.
• Alnabulsi et al. 2016. Characterisation of Arachidonic Acid Metabolising Enzymes in Colorectal Cancer. J Pathol. 240 Suppl 1:S1-S48. PMID: 27747872
• Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 June - 1 July 2016.