#151723

Anti-Cytochrome P450 2A6 [CYP2A6]

Cat. #151723

Anti-Cytochrome P450 2A6 [CYP2A6]

Cat. #: 151723

Sub-type: Primary antibody

Unit size: 100 ug

Target: Cytochrome P450 2A6, CYP2A6

Class: Polyclonal

Application: WB

Reactivity: Human

Host: Sheep

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Roland Wolf

Institute: University of Dundee

Tool Details
Target Details
Applications
Handling

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-Cytochrome P450 2A6 [CYP2A6]
  • Research fields: Cancer;Cell signaling and signal transduction;Genetics;Metabolism;Tissue-specific biology
  • Clone: CYP2A6
  • Tool sub type: Primary antibody
  • Class: Polyclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Sheep
  • Application: WB
  • Description: CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. CYP 2A6 exhibits high coumarin 7-hydroxylase activity and can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide.
  • Immunogen: Purified recombinant human P450s
  • Recommended controls: Human Liver Microsomes

Target Details

  • Target: Cytochrome P450 2A6, CYP2A6
  • Tissue cell line specificity: Human Liver Microsomes
  • Target background: CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. CYP 2A6 exhibits high coumarin 7-hydroxylase activity and can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide.

Applications

  • Application: WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Storage conditions: -80° C
  • Shipping conditions: Shipping at 4° C