Anti-cROS [4-6G]

Cat. #151666

Anti-cROS [4-6G]

Cat. #: 151666

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-5 days

Target: cROS

Class: Monoclonal

Application: IHC ; IF ; IP ; Fn ; WB

Reactivity: Human

Host: Mouse


This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.


Inventor: Al Charest

Institute: Tufts University

Tool Details
Target Details

Tool Details


  • Name: Anti-cROS [4-6G]
  • Clone: 4-6G
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; IF ; IP ; Fn ; WB
  • Description: Monoclonal antibody directed against cROS, a proto-oncogene with therapeutic target potential.
  • Immunogen: Extracellular portion of ROS amino acid 1-285 fused to Fc, transiently expressed in 293 cells and purified using PtnA column chromatography.
  • Immunogen uniprot id: P08922
  • Isotype: IgG1
  • Myeloma used: Sp2/0-Ag14
  • Recommended controls: Cells transiently expressing human cROS, mouse cells expressing human cROS

Target Details

  • Target: cROS
  • Tissue cell line specificity: Cells transiently expressing human cROS, mouse cells expressing human cROS
  • Target background: c-ROS is a proto-oncogene tyrosine kinase, that is highly-expressed in a variety of tumour cell lines and belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. It is a type I integral membrane protein and may function as a growth or differentiation factor receptor. The c-ROS gene promoter region has been identified and characterized and it has been shown that the ectopic expression of c-ROS in tumours is tied to hypomethylation of a CpG island in the c-ROS promoter. Tumours with ROS1 mutations are typically responsive to small molecule tyrosine kinase inhibitors.


  • Application: IHC ; IF ; IP ; Fn ; WB


  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4° C


  • Fei et al. 2019. Biosci Rep. 39(6):. PMID: 31138757.
  • Zhang et al. 2019. Int J Biol Sci. 15(7):1460-1471. PMID: 31337976.
  • Shih et al. 2017. Oncogene. 36(47):6542-6554. PMID: 28759046.
  • Deng et al. 2014. Int J Mol Med. 34(3):661-8. PMID: 24968753.
  • Charest et al. 2003. Proc Natl Acad Sci U S A. 100(3):916-21. PMID: 12538861.
  • Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma.