Anti-cROS [4-6G]

Monoclonal antibody directed against cROS, a proto-oncogene with therapeutic target potential.

Contributors

Inventor Institute
Al Charest Tufts University
Cat. #: 151666
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell signaling and signal transduction;Genetics
Application: IHC ; IF ; IP ; Fn ; WB
Target: cROS
Reactivity: Human
Clone: 4-6G
Host: Mouse
Class: Monoclonal
Product description: Monoclonal antibody directed against cROS, a proto-oncogene with therapeutic target potential.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Extracellular portion of ROS amino acid 1-285 fused to Fc, transiently expressed in 293 cells and purified using PtnA column chromatography.
Immunogen Uniprot ID: P08922
Myeloma used: Sp2/0-Ag14
Target background: c-ROS is a proto-oncogene tyrosine kinase, that is highly-expressed in a variety of tumour cell lines and belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. It is a type I integral membrane protein and may function as a growth or differentiation factor receptor. The c-ROS gene promoter region has been identified and characterized and it has been shown that the ectopic expression of c-ROS in tumours is tied to hypomethylation of a CpG island in the c-ROS promoter. Tumours with ROS1 mutations are typically responsive to small molecule tyrosine kinase inhibitors.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Fei et al. 2019. Biosci Rep. 39(6):. PMID: 31138757.

Zhang et al. 2019. Int J Biol Sci. 15(7):1460-1471. PMID: 31337976.

Shih et al. 2017. Oncogene. 36(47):6542-6554. PMID: 28759046.

Deng et al. 2014. Int J Mol Med. 34(3):661-8. PMID: 24968753.

Charest et al. 2003. Proc Natl Acad Sci U S A. 100(3):916-21. PMID: 12538861.

Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma.

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Adapted from Fei et al. 2019. Biosci Rep; 39(6). PMID

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